Exosomesreproductive medicineendometriosispolycystic ovary syndromeinfertilitydiseasesExosomes, small extracellular vesicles with diameters of 40-100nm, arc generated through the fusion of multivessel with plasma membrane and secreted by a variety of living cells. Exosomes contain lipid bilayer membrane and ...
Due to their regenerative and immunomodulatory properties, mesenchymal stromal cells (MSCs) have been reported to play a significant role in skin repair and regeneration. However, it seems that the secretome of these cells and exosomes in particular may be responsible for their functions in skin ...
particularly during systemic viral infections and certain autoimmune diseases characterized by high expression of ISGs called interferonopathies [1]. However, following infection by a virus, virtually any type of nucleated cell can produce IFNs via cytoplasmic sensing of viral-derived nucleotide...
Cancer immunotherapy has rapidly transformed cancer treatment, yet resistance remains a significant hurdle, limiting its efficacy in many patients. Circular RNAs (circRNAs), a novel class of non-coding RNAs, have emerged as pivotal regulators of gene expression and cellular processes. Increasing evidence...
New discoveries providing insights into mitochondrial bioenergetics, their dynamic interactions as well as their role in cellular homeostasis have dramatically advanced our understanding of the neurodegenerative process of Parkinson’s disease (PD). Respiratory chain impairment is a key feature in sporadic ...
[84]. In a recent study using a diabetic rat model, the wound area has been signifificantly improved with the use of exosomes of fat-derived stem cells (ADSCs) causing overexpression of Nrf2 [94]. However, a change in the Nrf2 gene might also render the wound area more vulnerable ...
The role of exosomes and miRNAs in drug-resistance of cancer cells Int. J. Cancer, 141 (2017), pp. 220-230 CrossrefView in ScopusGoogle Scholar 8 T. Wu, H. Zhou, Y. Hong, J. Li, X. Jiang, H. Huang miR-30 family members negatively regulate osteoblast differentiation J. Biol. Che...
It has been demonstrated that exosomes may be a potential therapeutic approach in various female reproductive diseases. In addition, changes in expression of microRNAs act as molecular biomarkers for diagnosis of several reproductive diseases in women, and regulation of their expression can potentially ...
The proliferation and metastasis ability of tumors are mediate by the "mutual dialogue" between cells in the tumor microenvironment (TME). Extracellular vesicles (EVs), mainly exosomes and microvesicles, play an important role in achieving intercellular
Extracellular vesicles (EVs) are vesicles derived from the endosomal system or plasma membrane of nearly all cell types released into the extracellular space. They are a type of lipid bilayer structure without a functional core and replicable capacity [1, 2]. EVs can be classified as exosomes (...