Estrogen receptorEstradiolOvarian cancerLeptin induces ovarian cancer cell invasion via overexpression of MMP7, MMP9, and upA. In addition, the key role of ERα in leptin-increased cell growth was indicated. However, the influence of ER on leptin-mediated cell invasion remains still unknown. The...
Acta Pharmacol Sin 2008 Dec; 29 (12): 1440–1450 Full-length article Estrogen plays a critical role in AAV2-mediated gene transfer in ovarian cancer1 Wen-fang SHI2,4, Jeffrey S BARTLETT3 2Laboratory of Gene and Viral Therapy, Eastern Hepatobiliary Surgical Hospital, Second Military Medical ...
Collagen is the major component of the tumor microenvironment and participates in cancer fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes, transcription factors, signaling pathways and receptors; furthermore, collage
In 2024, about 19,680 women in the United States will receive a new diagnosis of ovarian cancer and 12,740 women will die from the disease, said Dr. Shaina Bruce, a gynecologic oncologist at Penn State Cancer Institute. The median age of all patients who develop ovarian cancer is 63. Hi...
enhancer or its target gene specificity. These processes can generate tumour type-specific super-enhancers and establish a 'locked' gene regulatory state that drives the uncontrolled proliferation of cancer cells. Here, we review the role of enhancers in cancer, and their potential as therapeutic ...
K. Human ALKBH3-induced m1A demethylation increases the CSF-1 mRNA stability in breast and ovarian cancer cells. Biochim. Biophys. Acta Gene Regul. Mech. 1862, 35–46 (2019). Article CAS PubMed Google Scholar Konishi, N. et al. High expression of a new marker PCA-1 in human ...
Ovarian cancer is characterized by dysbiosis, referred to as oncobiosis in neoplastic diseases. In ovarian cancer, oncobiosis was identified in numerous compartments, including the tumor tissue itself, the upper and lower female genital tract, serum, per
1). Generally, EVs play a significant role in cellular dumping or the release of waste materials. EVs deliver various cargoes, including mRNAs, microRNAs (miRNAs), lipids, proteins, and nucleic acids, for long-distance communication between cells [3, 4]. Pathological cells, such as cancer ...
Abnormalities of the PI3K/AKT pathway in breast and female reproductive system tumor BC, which is Estrogen (ER)-related cancer, is the second common cancer in the world (morbidity of 11.6%) but in the first place and the most frequent cause of cancer death (mortality of 6.6%) among women...
a pan-cancer analysis. These data indicate that the roles of TXNIP in cancers show tumor specificity [14]. In addition to tumor-specific functions, TXNIP may also exert opposite functions at different stages during cancer progression. When analysing earlyvs. late-stage cases separately in ovarian...