ovarian epithelial carcinomaaromatase inhibitorsestrogen receptor antagonistsplatinum sensitivityBACKGROUND. In women, ovarian cancer is the eighth most frequent cancer in incidence and mortality. It is often diagnosed at advanced stages; relapses are frequent, with a poor prognosis. When platinum resistant...
If you are a premenopausal woman with high estrogen level, you may easily to get gallstones, varicose veins, uterine fibroids, cervical dysplasia, endometriosis, or ovarian cysts. In a word, high estrogen level could not only lead to endometriosis, but also could lead to endometrial cancer. ...
ovarian, endometrial, and cervical carcinomas, we examined the status of the FHIT gene in 14 ovarian, 8 cervical, and 4 endometrial human cancer cell ... DT Hendricks,R Taylor,M Reed,... - 《Cancer Research》 被引量: 208发表: 1997年 Analysis of FHIT transcripts in cervical and endometri...
High estrogen levels can increase your risk of: Breast and ovarian cancers Pain from endometriosis Insulin resistance PCOS Uterine cancer Tumors on your ovaries and adrenal glands Testosterone in Women Testosterone is made by your ovaries and adrenal glands (which are located on top of your kidneys...
Ovarian cystEndometriomaCA-125CA19-9Endometriosis is an estrogen dependent disease. Levels of Cancer antigen-125 are significantly higher in women with moderate to severe endometriosis. However, patients with unruptured endometriosis rarely have serum CA-125 levels more than 1000 U/mL. This case ...
Western blotting and qRT-PCR were used to detect the protein and mRNA expression of ETV5 in six ovarian cancer (OC) and human embryonic cell lines. Knockdown or overexpression of ETV5 in HGSOC cell lines, Cell Counting Kit-8, colony formation, and transwell assays were used to detect HG...
Although corroborating data indicate that estrogens influence glucose metabolism through the activation of the estrogen receptor alpha (ERalpha), it has not been established whether this pathway could represent an effective therapeutic target to fight against metabolic disturbances induced by a high-fat di...
High-grade serous ovarian cancer (HGSC) is the most common EOC and accounts for as many as 60% of EOC cases. Ovarian clear cell carcinoma (OCCC) is the second most common EOC, accounting for 5–11% of EOC cases [2, 3]. The demographic, morphological, and molecular features between ...
The epigenome offers an additional facet of cancer that can help categorize patients into those at risk of disease, recurrence, or treatment failure. We conducted a retrospective, nested, case-control study of advanced and recurrent high-grade serous ovarian cancer (HGSOC) patients in which we as...
An hitherto undefined androgen binding macromolecule(s), with high-capacity binding for natural and synthetic androgens, but not for estrogen and progesterone, seems to be present in these ovarian cancer tissues. The functionality of these androgen binding macromolecules in ovarian cancer is yet to ...