It has been suggested that cancer ought to be regarded as a disease of cell differentiation. In multicellular organisms, indeed, the control of cell multiplication is linked to cell specialization: During the process of differentiation embryonic cells, while cycling, acquire the ability to perform sp...
Research into the POU transcription factor Oct-6 has been the focus of much current attention, in particular its role in Schwann cell development and differentiation. Based on published data and data presented here, we propose a model for Oct-6 function at two distinct stages of Schwann cell ...
Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis. This is a preview of subscription content, access via your institution Access options ...
The organization of nucleosomes across functional genomic elements represents a critical layer of control. Here, we present a strategy for high-resolution nucleosome profiling at selected genomic features, and use this to analyse dynamic nucleosome positioning at inducible and cell-type-specific mammalian...
Wnts are a large family of conserved secreted carbohydrate and lipid-modified proteins that are involved in cell differentiation, proliferation and death [59]. They bind to cell-surface receptors of the Frizzled family and LRP-5/6, resulting in nuclear β-catenin translocation and specific gene ...
Five layers of receptor signalling in γδ T cell differentiation and activation. Front Immunol. 2015;6:15. Article PubMed PubMed Central CAS Google Scholar Nakamizo S, Egawa G, Tomura M, Sakai S, Tsuchiya S, Kitoh A, et al. Dermal Vc4 cd T cells possess a migratory potency to the...
In this review, I discuss recent findings about the contribution of cell death to the formation of sexually dimorphic neural circuitry and the regulation of sex-specific cell death by two sex determination factors, Fruitless and Doublesex, in Drosophila. 展开 关键词: courtship behavior Doublesex ...
The existence of several homologies between islet and neuronal cells lets us postulate that the factors influencing neuronal differentiation, such as NGF, could also play a role in islet cell differentiation program. As a first step, we have investigated the presence of NGF-R in a panel of ...
Structural basis for late maturation steps of the human mitoribosomal large subunit Article Open access 16 June 2021 Introduction Mitochondria are eukaryotic organelles with a central role in cell metabolism, regulation of apoptosis, cell differentiation, and innate immunity. They contain their own gene...
The mature protein product belongs to the family of cell–cell adhesion molecules and it plays a fundamental role in the maintenance of cell differentiation and the normal architecture of epithelial tissues [1., 2., 3., 4., 5., 6., 7.]. In fact, E-cadherin is a transmembrane homodimer...