A method for identifying the genetic factors responsible for cell differentiation based on expression cloning is described. To determine what genetic factor leads to the differentiation of a cell from a beginning cell type to a target cell type, a cDNA library is obtained, packaged in an ...
Key Laboratory of Cell Differentiation and Apoptosis, Ministry of Education, Department of Pathophysiology, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China Zhimin Huang, Junxing Zhao, Yingyi Chen, Jialin Shang, Kun Song, Lu Zhang, Chengxiang Wang, Shaoyong Lu, Xi...
V. The roles of PARP1 in gene control and cell differentiation. Curr. Opin. Genet. Dev. 20, 512–518 (2010). Article CAS PubMed PubMed Central Google Scholar Kim, M. Y., Zhang, T. & Kraus, W. L. Poly(ADP-ribosyl)ation by PARP-1: 'PAR-laying' NAD+ into a nuclear signal....
Cells are continuously exposed to various stress factors that endanger their functionality and thus, their ability to cope with stress. The ability of cells to adapt and survive by restoring homeostasis is an integral component of cellular physiology. However, if the stress is persistent and homeosta...
OPG is a cytokine receptor expressed by osteoprogenitor cells and osteoblasts to inhibit the differentiation of osteoclasts and to control the bone resorption; thus, the rise in OPG concentration could be related to bone anabolic metabolism [10,38,39]. IL-8 was also higher for pOB + G ...
Since the RNA translation product is responsible for biological activities of genes, we next examined the cellular levels of Nrf2 and Prdx6 protein. Under the same conditions of experiments, Western blot analysis of total extract isolated from the Hyd-treated and untreated lenses of 16 M old C57...
T-cell differentiation, proliferation, and apoptosismiRNA-101ICOSDownregulates IL-2 production; inhibits co-stimulation signals of T cells. miRNA-184NFAT1IL-2Suppressor of T-cell activity. miRNA-155CTLA4Promotes T-cell proliferation enhancing CD28 signaling. ...
Opsis Therapeutics is a company focused on advancing the pipeline of cell replacement therapies targeting ocular diseases. Leveraging innovations in induced iPSC generation, retinal cell differentiation, and functional biomaterials, Opsis...
[1]. The isoprenoid side chain is responsible for the lipid-soluble nature of CoQ, whereas its antioxidant capacity derives from its quinone head, which can enable electron transfer (Fig.1). Because of this electron-sequestering property, CoQ10acts as an antioxidant at cellular membranes to ...
In the presence of oxidative stress, the Wnt/β-catenin pathway can be activated, leading to the accumulation and nuclear translocation of β-catenin; this promotes the transcription of target genes involved in cell proliferation and differentiation [39]. ...