Hypoxia stimulated the expression of RNF144A-AS1 in a HIF-1伪-independent manner. Additionally, RNF144A-AS1 was also induced by TGF-尾1. Loss and gain of function assays revealed that RNF144A-AS1 promoted tumor metastasis, angiogenesis, and proliferation. Mechanism exploration indicated RNF144A...
Mechanistically, as a high-risk prognostic factor, RNF144A-AS1 regulated biological processes of SKCM by interacting with TAF15 through an RNA-binding protein-dependent (RBP-dependent) manner. Furthermore, we confirmed that TAF15 activated downstream transcriptional regulation of YAP1 to modulate ...
RNF144A-AS1 has good potential in tumor treatment and diagnosis.doi:10.1007/s12013-024-01411-9Wei WuXiaolan LiXueqing LiJiale ZhaoYibei GuiYiyang LuoHailin WangLijun WangChengfu YuanCell Biochemistry and Biophysics
本发明涉及检测血清外泌体RNF144AAS1的引物,试剂盒及其在胃癌肝转移诊疗中的应用,试剂盒包括血清lncRNA样本的RNA提取试剂,引物,去基因组DNA反应体系,逆转录反应体系,qPCR操作反应体系,本发明公开了lncRNA在胃癌患者及正常人血清外泌体中的表达情况,并用荧光定量PCR检测RNF144AAS1.血清外泌体RNF144AAS1可用于胃癌...
长链非编码RNA RNF144A-AS1临床病理特征预后膀胱癌是全球常见恶性肿瘤,且膀胱癌在男性泌尿生殖系统中最为常见[1].膀胱癌早期患者自身往往较难发现,其就诊一般出现无症状性血尿或日常体检[2,3].长链非编码RNA RNF144A-AS1(lncRNA RNF144A-AS1)是一种与膀胱癌细胞迁移,侵袭及总生存率有关的lncRNA.但目前关于...
However, the biological role and potential molecular mechanism of lncRNA RNF144A-AS1 in liver metastasis of gastric cancer(GCLM) remain unclear. Methods: LncRNAs associated with GCLM were identified by microarray. Gain or loss of function approaches was used to investigate the biological functions ...