同时,qRCR结果显示:与正常背根神经节相比,HNF4A-AS1在NB细胞系中表达升高,且在两个 NB 细胞中,HNF4A-AS1 呈现中度或高表达水平(Fig 1B)。接着作者分别选择SH-SY5Y和BE(2)-C作为HNF4A-AS1异位表达或沉默的模型,用空载、H...
Mechanistically, transcription factor HNF4A increased the expression of hexokinase 2 (HK2) and solute carrier family 2 member 1 (SLC2A1), while HNF4A-AS1 bound to heterogeneous nuclear ribonucleoprotein U (hnRNPU) to facilitate its interaction with CCCTC-binding factor (CTCF), resulting in ...
HNF4A-AS1/hnRNPU/CTCF axis as a therapeutic target for aerobic glycolysis and neuroblastoma progression Journal of Hematology & Oncology (2020) -5Comments doi: 10.1186/s13045-020-00857-7 issn: 1756-8722 pubmed: 32216806 Huajie Song,Dan Li,Xiaojing Wang,Erhu Fang,Feng Yang,Anpei Hu,Jianqun ...
Administration of a small peptide blocking HNF4A-AS1-hnRNPU interaction or lentivirus-mediated short hairpin RNA targeting HNF4A-AS1 significantly suppressed aerobic glycolysis, tumorigenesis, and aggressiveness of NB cells. In clinical NB cases, high expression of HNF4A-AS1, hnRNPU, CTCF, or HNF4...
HNF4A-AS1 inhibits the progression of hepatocellular carcinoma by promoting the ubiquitin-modulated degradation of PCBP2 and suppressing the stability of ARG2 mRNAdoi:10.7150/ijbs.95276Wenbo JiaLiang YuBin XuYanzhi FengJinyi WangDeming ZhuChao Xu...
Decreased lncRNA HNF4A-AS1 facilitates resistance to sorafenib-induced ferroptosis of hepatocellular carcinoma by reprogramming lipid metabolismdoi:10.7150/thno.99197Yong ZhaoShengbo HanZhu ZengHai ZhengYang LiFan WangYan HuangYingsong ZhaoWenfeng Zhuo...