为进一步探索RNase1对肝癌肿瘤微环境的调控作用,研究团队构建了小鼠原位肝癌模型,利用质谱流式技术(CyTOF)检测发现,过表达RNase1的小鼠肿瘤中,肿瘤相关巨噬细胞(Tumor-associated macrophage, TAM),中性粒细胞(Neutrophil)以及单核细胞(Monocyt...
decreased production of pro-tumorigenic factors including IL-6, IL-8, chemokine (C-X-C) ligand 1 (CXCL1), transforming growth factor β 2 (TGFβ2), and granulocyte-macrophage-colony-stimulating-factor (GM-CSF), linking constitutive IRE1 RNase activity to maintenance of a pro-tumorigenic ...