在底物识别方面，RNase MRP摒弃了RNase P所采用的双锚定机制，但在催化核心上，则完全保留了RNase P所采用的双镁离子SN2催化反应机理。 一个核心而关键的问题是：究竟是什么决定了RNase MRP的底物特异性？结合RNase MRP-底物复合物的结构以及体外生化实验表明，位于RNase MRP底物结合口袋周围的几个关键蛋白质亚基相较...
Ribonuclease P (RNase P) is an essential endonuclease that catalyzes the cleavage of the 5′ leader sequence from precursor tRNAs (pre-tRNAs). Most forms of RNase P are ribonucleoproteins and the bacterial enzyme possesses a single catalytic RNA and one
known functions of RNase P/MRP to endoribonucleolytic cleavage of m6A RNAs. 中文翻译: RNase P/MRP 复合物对含 m6A 的 RNA 的内切核糖核酸裂解 N6-甲基腺苷 (m6A) 是 RNA 中最丰富的内部修饰,在各种生物和生理过程中发挥调节作用。尽管具有重要作用,但对 m6A 介导的基因调控的分子机制知之甚少。在这里...
RNase MRP has been implicated in the processing of precursor-rRNA, whereas RNase P has been shown to function in the processing of pre-tRNA. Both ribonucleoprotein particles have an RNA component that can be folded into a similar secondary structure and share several protein components. We have ...
RNase MRP is a ribonucleoprotein particle involved in the processing of pre-rRNA. The RNase MRP particle is structurally highly related to the RNase P particle, which is involved in pre-tRNA processing. Their RNA components fold into a similar secondary structure and they share several protein sub...
RNase MRP是存在于所有真核生物中一类保守的由一条非编码RNA催化亚基和近十个蛋白质组成的核糖核酸复合物。它在核糖体rRNA前体成熟过程和细胞周期调控中都扮演着重要的角色。人源RNase MRP RNA组分的突变导致以侏儒、软骨及毛发发育不良等为显著特征的严...