以及所述lncRNARP11290F20.3的小干扰RNA在制备用于预防或治疗胃癌疾病的药物中的用途.本发明所述的lncRNARP11290F20.3在人类胃癌组织和胃癌细胞系中高表达,而lncRNARP11290F20.3的小干扰RNA具有抑制胃癌细胞增殖,侵袭和迁移的功能,因此,lncRNARP11290F20.3的小干扰RNA可以作为一种新型的药物作用靶点,对于胃癌的预防及...
Silencing of Long Non-coding RNA RP1-93H18.6 Acts as a Tumor Suppressor in Cervical Cancer through the Blockade of the PI3K/Akt AxisThis article has been retracted: please see Elsevier Policy on Article Withdrawal ( http://www.elsevier.com/locate/withdrawalpolicy ). This article has been ...
我们使用RNA结合蛋白(RBP)捕获来确定mTOR抑制后蛋白质-RNA相互作用格局的变化。 当mTOR被抑制时,LARP1与一些mRNA的结合增加,包括含有"TOP"结构的的mRNA。 重要的是,即使在控制条件下,LARP1结合的不包含“TOP”的mRNAs也处于翻译抑制状态。 我们的数据表明,LARP1相关蛋白PABPC1的mRNA相互作用组与LARP1有高度的重叠,...
circLARP1B中基序1或基序2的突变降低了circLARP1B和HNRNPD之间的相互作用,这而两个基序的双突变则直接消除了相互作用。 HNRNPD与mRNA结合可以调节RNA的稳定性,敲低HNRNPD并不影响circLARP1B的水平,表明HNRNPD并不调节circLARP1B的稳定性。反过来敲低circLARP1B也不影响HNRNPD mRNA和蛋白的水平。综上所述,具有...
Here we show that LARP1 is the most expressed LARP in mouse islets and human β‑cells, being 2–4‑fold more abundant than LARP1B, a member of the family that also interacts with mTORC1. Interestingly, β‑cells from diabetic patients have higher LARP1 and LARP1B expression. ...
刚毛柽柳富含甘氨酸RNA结合蛋白ThGRP1基因克隆与表达分析
The aim of this study is to reveal the functional mechanism of lncRNA ARFRP1 and miR-15a-5p in osteoarthritis. Materials and methods The expression level of genes was detected by quantitative real time polymerase chain reaction (qRT-PCR) or western blot assay. Cell Counting Kit-8 (CCK-8) ...
Mechanistic target of rapamycin complex 1 (mTORC1) deficiency or chronic hyperactivation in pancreatic β-cells leads to diabetes. mTORC1 complexes with La-related protein 1 (LARP1) to specifically regulate the expression of 5′ terminal oligopyrimidine
产品名称:Mouse NCCRP1 shRNA Plasmid 产品型号:abx982019 产品展商:其它品牌 产品文档:无相关文档 简单介绍 Mouse NCCRP1 shRNA Plasmid Mouse NCCRP1 shRNA Plasmid的详细介绍 shRNA Plasmid to inhibit NCCRP1 expression by RNA interference. This product contains 3 separate slightly different shRNA sequence...
(3)mRNA是翻译的模板,核酶通过切断靶RNA(病毒mRNA)特定部位上两个相邻核糖核苷酸之间的磷酸二酯键来裂解靶RNA,从而阻止翻译过程,抑制病毒复制。 (4)染料木黄酮能抑制rRNA形成,使细胞中缺乏rRNA,导致RP1与mRNA分子上的RBS位点结合从而终止核糖体蛋白的合成,进而减少细胞中核糖体的数量,降低蛋白质合成的速率,抑制癌细胞...