2023年11月18日,Nature Communications在线发表了同济大学刘琦团队、罗氏中国创新中心Qing Zhang、中国农业科学院农业基因组研究所左二伟团队合作的研究成果:‘Genome-wide CRISPR off-target prediction and optimization using RNA-DNA interaction fingerprints’,这篇文章介绍了一种新的预测脱靶的工具——CRISOT,该工具结...
while they also involve the interaction of RNA-DNA hybrid. Although not quite proper, off-target prediction methods of Cas9 were usually used to evaluate the off-target effects of BEs and PEs including BE3, ABE7.10 and PE2 etc. Here, we curated Group...
et al. The interaction of PRC2 with RNA or chromatin is mutually antagonistic. Genome Res. 26, 896–907 (2016). Article PubMed PubMed Central CAS Google Scholar Zhang, Q. et al. RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2. Nat. Struct. Mol. ...
Prediction of Transcription Factor Families Using DNA Sequence Features Understanding the mechanisms of protein-DNA interaction is of critical importance in biology. Transcription factor (TF) binding to a specific DNA sequence ... A Anand,GB Fogel,G Pugalenthi,... - Pattern Recognition in Bioinforma...
Understanding protein structures is necessary to determine the function of a protein and its interaction with DNA, RNA and Enzymes. Experimental techniques such as... A Deka,AK Sarma - 《International Journal of Computer Applications》 被引量: 10发表: 2013年 Protein structure prediction and ...
Moreover, we address the need for better diagnostics, antibiotic resistance prediction, contamination discrimination, and prognosis of IM by integrating host response and DNA/RNA microbe detection. These results may provide an important basis for diagnosing and treating IM....
GraphRBF is a state-of-the-art protein-protein/nucleic acid interaction site prediction model built by enhanced graph neural networks and prioritized radial basis function neural networks. This project serves users to use our software to directly predict protein binding sites or train our model on ...
In order to further verify the performance of the model, we assessed EPDRNA for the prediction of DNA-binding sites and the prediction of RNA-binding sites on the independent test dataset. The EPDRNA achieved 85% recall rate and 25% precision on the protein–DNA interaction independent test ...
DNA or RNA-binding residues may have the size constraint to be fitted into the interaction interface, and the mean and standard deviation of M may be used to represent the evolutionary information for the size constraint. Classifier evaluation A fivefold cross-validation approach was used to ...
259Altmetric Metrics Abstract Knowing the sequence specificities of DNA- and RNA-binding proteins is essential for developing models of the regulatory processes in biological systems and for identifying causal disease variants. Here we show that sequence specificities can be ascertained from experimental da...