To further decrease the impact of false favorable rates, the predicted interaction of hsa-miRNA:3′UTR was corroborated using scores from highly cited prediction tools such as RNAhybrid, miRanda, and mirTarP. These three tools matched 20 pairings in SARS-CoV, of which 15 (75%) showed to be...
(V) changes the interaction pattern, leading to the formation of two hydrogen bonds between mutant V97 and N136 and L40 (Figure 3A,B). These changes can provide more stability and less flexibility to the protein, which supports previous experiments. Likewise, mutation of P with hydrophobic I ...