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Functional RNA secondary structure is important for the pre-mRNA processing including splicing, cleavage and polyadenylation, and RNA editing. Here the authors present a catalog of conserved long-range RNA structures in the human transcriptome by defining pairs of conserved complementary regions (PCCR) ...
The process of RNA editing can occur in various types of RNA molecules, including pre-mRNA, mature mRNA, miRNA, lncRNA, tRNA, and even viral RNA [11,12,13]. An important impact of RNA editing is its ability to challenge the central dogma of biology. When RNA editing takes place in th...
作为RNA editing领域的研究热点,RESC具有很强的组分不均一性和多种功能状态,这使得其机制解析具有极高的挑战性。 2023年7月6日,加州大学洛杉矶分校(UCLA)周正洪课题组与波士顿大学(BU)Ruslan Afasizhev课题组、上海科技大学张力烨课题组、加州大学尔...
select article Epididymis-specific RNase A family genes regulate fertility and small RNA processing Research articleOpen access Epididymis-specific RNase A family genes regulate fertility and small RNA processing Joshua F. Shaffer, Alka Gupta, Geetika Kharkwal, Edgardo E. Linares, ... Upasna SharmaDec...
1月4日,中国科学院-马普计算生物学研究所杨力研究组和中国科学院生物化学与细胞生物学研究所陈玲玲研究组在Molecular Cell杂志上在线发表了题为 “N6-methyladenosines modulate A-to-I RNA editing” 的最新研究成果,揭示了两种最为普遍存在的 RNA 水平修饰-腺苷 N6 位置上的甲基化 (m6A) 和腺苷至次黄苷碱基编辑...
of S-5 in the CTD promotes transcription by causing RNA polymerase II to dissociate from the initiation complex and by recruiting thecapping enzyme. The switch to phosphorylation on S-2 promotes elongation and processing by recruiting factors for splicing, poly(A) tail synthesis, and so on. ...
A critical step in uncovering rules of RNA processing is to study the in vivo regulatory networks of RNA binding proteins (RBPs). Crosslinking and immunoprecipitation (CLIP) methods enable mapping RBP targets transcriptome-wide, but methodological differ
The endogenous adenosine deaminases acting on RNA (ADAR) have been harnessed to facilitate precise adenosine-to-inosine editing on RNAs. However, the practicability of this approach for therapeutic purposes is still ambiguous due to the variable expressi
RNA processing plays a central role in accurately transmitting genetic information into functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to observe RNA with high spatial and temporal resolution are critical. Here we review recent advances in RNA imaging and highlig...