instance, certain genes (CCNI, COPA, and AZIN1) exhibit more alterations in endothelial cells compared to excitatory neurons, while TMEM63B shows less alteration in endothelial cells [17,18]. It has demonstrated that ADARs play crucial roles in brain development, viral defense mechanisms [19,20,...
complement of Central Dogma.While RNA interference is a gene regulate pathway of blocking gene expression,triggered by double-stranded RNA at the level of transcription,post-transcription and translation.Introduced the functions of RNA editing and the relationship between RNA editing and RNA interference...
In this review, the structural properties and expression of PDIs in cancer are discussed. We describe existing and emerging roles as well as molecular mechanisms in supporting key biological processes in cancer emergence, with special emphasis on the anterior gradient (AGR) subfamily. In addition, t...
Indeed, non-histone protein acetylation is involved in key cellular processes relevant to physiology and disease, such as gene transcription, DNA damage repair, cell division, signal transduction, protein folding, autophagy and metabolism. Acetylation affects protein functions through diverse mechanisms, ...
RNA, complex compound of high molecular weight that functions in cellular protein synthesis and replaces DNA as a carrier of genetic codes in some viruses. RNA consists of ribose nucleotides and the nitrogenous bases adenine, guanine, cytosine, and uraci
major families of polynucleotide editing enzymes, the AID/APOBEC cytidine deaminases (which catalyze the deamination of cytidine to uridine) and the adenosine deaminases acting on RNA (ADARs, which catalyze the deamination of adenosine to inosine), function in a variety of host defense mechanisms. ...
This review provides a structural comparison of His-Me finger nucleases, summarizing their substrate recognition strategies, catalytic mechanisms, cellular functions, and the various means of activity regulation. The historical name of the His-Me finger family, HNH, was based on sequence homology among...
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Mechanisms of alternative pre-messenger RNA splicing. Annu. Rev. Biochem. 72, 291–336 (2003). CAS PubMed Google Scholar Nilsen, T. W. & Graveley, B. R. Expansion of the eukaryotic proteome by alternative splicing. Nature 463, 457–463 (2010). CAS PubMed PubMed Central Google Scholar...
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