An interesting regulatory capacity of other noncoding RNA is found from lncRNA (CCAT1), which acts as a miRNA sponge and a new type of lncRNA uses ultraconserved regions (UCRRNA, see below) of DNA sequences found in exon or intron regions.144 ...
RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook journalist (redirected fromJuornalist) Thesaurus jour·nal·ist (jûr′nə-lĭst) n. 1.One whose occupation is journalism. 2.One who keeps a journal. ...
Steitz and colleagues discovered positive action by miRNAs - they found that the human TNFa mRNA activates translation during serum starvation, which arrests the cell cycle in the G1 phase.人TNFa mRNA在血清缺乏时激活翻译,使细胞周期停滞在G1阶段...
2021年3月22日，华侨大学医学院基因组学研究所Philipp Kapranov教授团队在Nature Chemical Biology期刊上在线发表了文章 Hovlinc is a recently evolved class of ribozyme found in human lncRNA ，在人类基因组中发现了一种全新类型的自切型核酶——hovlinc 核酶，这是首次在人类超长链基因间非编码RNA（vlincRNA）...
19,20; see Methods) still resulted in silencing, indicating that initiation is independent of maternal chromatin in the germline of progeny. Because PRG-1 loss abolished mating-induced silencing of gfp in T (Fig. 2a, b) and because Tgfp (Pmex-5::gfp::cye-1 3′ UTR) was also silenced...
to the term "non-coding RNA", "extracellular RNA" defines a group of several types of RNAs whose functions are diverse, yet they share a common attribute which, in the case of exRNAs, is existence in an extracellular environment. The following types of RNA have been found outside the ...
RNA interference (RNAi) is involved in genome defense as well as diverse cellular, developmental, and physiological processes. Key components of RNAi are Argonaute, Dicer, and RNA-dependent RNA polymerase (RdRP), which have been functionally characterized mainly in model organisms. The key components...
in Drosophila cells. GR foci do not form at random positions but rather require specific interactions with certain chromatin regions probably acting as nucleation centers. They also found that active GR molecules coexist with t...
This modification was observed in different types of RNA, including mRNA and small regulatory RNA (sRNA)20. However, little is known about the biological functions of this RNA cap21. Fig. 1: Mechanisms of ADP-ribosylation and proposed RNAylation. a, The mechanism of ADP-ribosylation for Arg...
4 is currently being evaluated in phase II clinical trials for the treatment of chronic hepatitis virus C (HCV) infection. Janssen screened a series of 4′-cytosine nucleoside analogues based on their pharmacodynamics and pharmacokinetic properties and found that 4′-chloromethyl-2′-deoxy-2′-...