However, the relative contribution of each of these RNA species to RIG-I activation and interferon induction in virus-infected cells is not known. Here, we use three approaches to identify physiological RIG-I agonists in cells infected with influenza A virus or Sendai virus. We show that RIG-...
Steitz and colleagues discovered positive action by miRNAs - they found that the human TNFa mRNA activates translation during serum starvation, which arrests the cell cycle in the G1 phase.人TNFa mRNA在血清缺乏时激活翻译,使细胞周期停滞在G1阶段...
Coincidentally, the r(UGGAA)n repeat sequence is also found in the HSATIII long noncoding RNAs (lncRNAs), which are transcribed from Satellite III pericentromeric repeat upon thermal stress exposure37. HSATIII lncRNAs also sequester multiple RBPs to form RNA foci called nSBs in the nucleus. ...
The precise regulation of gene expression is fundamental to neurodevelopment, plasticity and cognitive function. Although several studies have profiled transcription in the developing human brain, there is a gap in understanding of accompanying translati
If in the nucleus, what nuclear proteins are in association with a newly formed circRNA? How does a circRNA export from the nucleus to the cytoplasm for cytoplasmic PKR interaction? During virus infection or poly I:C stimulation, which dsRNA-binding factor is activated first, RNase L or PKR?
An interesting regulatory capacity of other noncoding RNA is found from lncRNA (CCAT1), which acts as a miRNA sponge and a new type of lncRNA uses ultraconserved regions (UCRRNA, see below) of DNA sequences found in exon or intron regions.144 ...
The pri-miRNA appears to be processed by the RNAse Drosha in the nucleus, cleaving the RNA at the base of the stem-loop [25]. This cut defines one end of the microRNA. The precursor microRNA is then exported by Ran-GTP and Exportin-5 to the cytoplasm, where it is further processed...
DNA's Location in Cells Most DNA is located inthe cell's nucleus.The nucleus is the control center of the cell, and it determines how the cell will function. Small amounts of DNA can also be found in the mitochondria, another organelle in cells whose function is to convert energy from ...
RNA-protein interactions (RPIs) play important roles in a wide variety of cellular processes, ranging from transcriptional and post-transcriptional regulation of gene expression to host defense against pathogens. High throughput experiments to identify R
DNA-based vaccines are designed by inserting the gene encoding the desired antigen into a circular DNA plasmid. This plasmid is then administered directly into the body through intramuscular or intradermal injection [230]. Once inside the cells, the DNA plasmid is taken up by the nucleus, where...