MicroRNA is a single-stranded RNA molecule, approximately 22 nucleotides long, that plays a significant role in post-transcriptional gene expression regulation by forming a distinct hairpin conformation and being processed into mature microRNAs.
RNAis a single-strandedpolynucleotidecontaining thenucleosidesadenosine,guanosine,cytosine, anduridine. Roughly one-third to one-half of the nucleotides are engaged in intra-strandhydrogen bonds, with single-stranded segments interspersed between double-stranded regions that contain up to about 30 base pai...
Figure 2. (a) DNA is typically double stranded, whereas RNA is typically single stranded. (b) Although it is single stranded, RNA can fold upon itself, with the folds stabilized by short areas of complementary base pairing within the molecule, forming a three-dimensional structure. Think about...
Deoxyribonucleic acid or DNA is a molecule made of two polynucleotide chains. These coils form a complexdouble helixcarrying genetic instructions for the development, functioning, growth, and reproduction of all living organisms. The two strands of double-stranded DNA store the same biological informati...
A monomer for synthesizing a nucleic acid molecule, the monomer having a structure represented by the following formula (II) ** Formula ** where X1 is, O, S or NH or, together with the carbon atom to which it is attached , forms a methylene group; independently of X1, X2 is O, S...
A nucleic acid present in all living cells and many viruses, consisting of a long, usually single-stranded chain of alternating phosphate and ribose units, with one of the bases adenine, guanine, cytosine, or uracil bonded to each ribose molecule. RNA molecules are involved in protein synthesis...
2024年4月23日，中国科学院分子细胞科学卓越创新中心陈玲玲研究组在Nature Biotechnology期刊上发表了文章Therapeutic application of circular RNA aptamers in a mouse model of psoriasis。该研究通过优化RNA自剪接成环，实现了合成低免疫原性的具有分子内短双链结构的环形RNA（short double-stranded region containing ...
2. The diagram below represents a DNA nucleotide. Identify the phosphate group and deoxyribose. [1 mark] 3. Draw a labelled diagram to show how four nucleotides are joined together to form a double-stranded DNA molecule with two base pairs. [3 marks] 4. State two differences between RNA...
Drosophila Dicer-2 (Dcr-2) produces small interfering RNAs from long double-stranded RNAs (dsRNAs), playing an essential role in antiviral RNA interference. The dicing reaction by Dcr-2 is enhanced by Loquacious-PD (Loqs-PD), a dsRNA-binding protein that partners with Dcr-2. Previous biochemi...
RNA molecules usually possess a variety of single-stranded and double-stranded regions that give rise to complex three-dimensional structures. These structures probably define the molecule's interactions with other nucleic acids, proteins, and small molecules. The ...