MicroRNA is a single-stranded RNA molecule, approximately 22 nucleotides long, that plays a significant role in post-transcriptional gene expression regulation by forming a distinct hairpin conformation and being processed into mature microRNAs.
The short hairpin RNA (shRNA) is a single-stranded molecule that gains short hairpin tertiary structure by folding in itself to form a stem-loop structure. From: Animal Models in Cancer Drug Discovery, 2019 About this pageSet alert Also in subject area: NeuroscienceDiscover other topics On thi...
A single-stranded RNA molecule comprising an expression inhibitory sequence that inhibits expression of a target gene, where: - the molecule comprises a region (Xc), a linker region (Lx) and a region (X); - the region (X) comprises the inhibiting sequence expression; - the region (Xc) ...
Structures of the Dcr-2–Loqs-PD complex while it is processing a double-stranded RNA (dsRNA) substrate elucidate the interactions between Dcr-2 and Loqs-PD, and show that Dcr-2 undergoes substantial conformational changes during a dsRNA-processing cycle. Shichen Su , Jia Wang & Jinbiao Ma ...
adenine (A), guanine (G), cytosine (C), thymine (T), uracil(U) 】 【3】While the structure of DNA is a double-helix in eukaryotic cells, RNA is typically single-stranded and comes in various forms. The single-stranded structure of RNA ...
RNA folding is the process by which a linear ribonucleic acid (RNA) molecule acquires secondary structure through intra-molecular interactions. The folded domains of RNA molecules are often the sites of specific interactions with proteins in forming RNAprotein (ribonucleoprotein) complexes. Latest Re...
Its full form isRibonucleic acid.This isa polymer of subunitsjoined by phosphodiester bonds. It is a single-stranded nucleic acid similar to DNA but having ribose sugar rather than deoxyribose sugar and uracil instead of thymine as on...
A cryo-EM structure of HrAgo1, combined with quantitative single-molecule experiments, reveals that the protein displays structural features and target-binding modes that are a mix of those of eukaryotic AGO and PIWI proteins. Thus, this deep-branching archaeal PIWI may have retained an ancestral...
2016年6月，该领域的“大神”、美国Broad研究所的张锋获得了一项重要成果。在一篇Science论文中，他带领的团队首次描述了一种RNA靶向的CRISPR酶——C2c2（现在被称为 Cas13a）。与CRISPR/Cas9切割DNA的活性不同，CRISPR/Cas13a能够用于切割细菌细胞中特定的RNA序列。Cas13a bound to and cleaving single-stranded RNA...
2.6.S1 Drawing simple diagrams of the structure of single nucleotides of DNA and RNA, using circles, pentagons, and rectangles to represent phosphates, pentoses and bases. 核苷酸由三种物质组合而成: 含氮碱基(nitrogenous base):与1号碳原子连接,DNA的4个碱基是cytosine (C), guanine (G), adenine...