DOUBLE-STRANDED RNA MOLECULE AND PHARMACEUTICAL USE THEREOFProvided are a double-stranded RNA molecule and pharmaceutical use thereof. The RNA is derived from Ganoderma lucidum (Curtis:Fr.) P. Karst., and has a prophylactic and therapeutic effect on tumors....
Image depicting how a double-stranded DNA molecule unwinds Image: Wikipedia 描绘双链 DNA 分子如何展开的图像 【unwinds 解开,打开,松开(卷绕之物)】 【6】Even though a DNA molecule is two-stranded, only one of the stra...
This study demonstrates the feasibility of mapping R-loops genome-wide at high resolution by capturing and sequencing the single-stranded DNA of the displaced strand, providing additional insights into the principles underlying R-loop formation. It is a valuable complementary approach to DNA–RNA ...
Although RNA is a single-stranded molecule, researchers soon discovered that it can form double-stranded structures, which are important to itsfunction. In 1956, Alexander Rich—an X-ray crystallographer and member of the RNA Tie Club—and David Davies, both working at the National Institutes ...
3. Draw a labelled diagram to show how four nucleotides are joined together to form a double-stranded DNA molecule with two base pairs. [3 marks] 4. State two differences between RNA and DNA nucleotides. [2 marks] Reference: Clegg, C. Biology for the IB Diploma (2nd ed.). Hodder Educ...
Although DNA is a double-stranded molecule, only one of the strands encodes information that the RNA polymerase reads to produce mRNA. The promoter specifies where mRNA synthesis starts, and which DNA strand serves as the template strand. RNA polymerase binds the proximal promoter region aided by...
Four double-stranded regions calledstems(or arms) often contain GU base pairs. The names of the stems match the corresponding loop. 6. Another loop, containing bases 44–48, is also present. In the smallest tRNAs it contains four bases, whereas in the largest tRNA molecule it contains 21 ...
2024年4月23日，中国科学院分子细胞科学卓越创新中心陈玲玲研究组在Nature Biotechnology期刊上发表了文章Therapeutic application of circular RNA aptamers in a mouse model of psoriasis。该研究通过优化RNA自剪接成环，实现了合成低免疫原性的具有分子内短双链结构的环形RNA（short double-stranded region containing ...
该研究通过优化RNA自剪接成环的新方法，实现了大规模合成低免疫原性且具有特殊双链结构环形RNA适配体（short double-stranded region-containing circular RNAs, ds-cRNAs）。利用单分子全内反射荧光显微镜（single-molecule total internal reflection fluorescence, smTIRF）在单分子水平阐明了ds-cRNA与PKR的作用机制，PKR...
Figure 2. (a) DNA is typically double stranded, whereas RNA is typically single stranded. (b) Although it is single stranded, RNA can fold upon itself, with the folds stabilized by short areas of complementary base pairing within the molecule, forming a three-dimensional structure. ...