2019,Molecular Biology (Third Edition) Chapter Kinetic Behavior of Enzyme Inhibitors 8.12.10RNA Interference is an Under-Explored Way to Deplete Target Enzymes Although pharmaceutical firms have traditionally f
Howard KA. RNA Interference from Biology to Therapeutics . New York: Springer; (2012).Howard KA. RNA Interference from Biology to Therapeutics. New York: Springer (2012).Pittella, F. & Kataoka, K. in RNA Interference from Biology to Therapeutics (ed. Howard, K. A.), 161-184 (Springer ...
VI. The Future of RNA Interference in Biology and Medicine Even at this early stage of understanding the molecular mechanisms of RNAi and in the development of methods for the use of RNAi technology for selective gene silencing, it is clear that RNAi will be a widely used tool for establishin...
Single-stranded, DNA-damage-associated small RNAs generated by a BRCA1–RNA-interference complex promote PALB2–RAD52-mediated DNA repair at transcriptional termination pause sites that contain R-loops and are rich in single-stranded DNA breaks in both quiescent and proliferating cells. ...
Mello, the two 2006 Nobel laureates "for their discovery of RNA interference - gene silencing by double-stranded RNA" (http://nobelprize.org/nobel_prizes/medicine/laureates/2006/). Well, it is impressive how both the Nobel laureates clearly anticipate the immense possibility the phenomenon they ...
RNA interference, or RNAi, is a widely used technique in which double stranded RNA is introduced to an organism, resulting in targeted gene silencing. The Nobel winning discovery of RNA interference allowed researchers to silence any C. elegans gene in order to determine its function. We can in...
Double-stranded RNA-mediated interference (RNAi) is a simpleand rapid method of silencing gene expression in a range oforganisms. The silencing of a gene is a consequence of degradationof RNA into short RNAs that activate ribonucleases to targethomologous mRNA. The resulting phenotypes either are ...
regulation. Duplexed RNAs can be substrates, modulators or cargos for dsRBM proteins. There are extensive interactions between dsRBM proteins. Some are involved in the same cellular pathway, such as the interferon response and RNA interference, whereas some seem to modulate the functions of others...
RNA interference (RNAi) is a regulatory cellular process that controls post-transcriptional gene silencing. During RNAi double-stranded RNA (dsRNA) induces sequence-specific degradation of homologous mRNA via the generation of smaller dsRNA oligomers of length between 21-23nt (siRNAs). siRNAs are then...
BMC Molecular Biology volume 8, Article number: 98 (2007) Cite this article 14k Accesses 53 Citations Metrics details Abstract Background Effective and stable knockdown of multiple gene targets by RNA interference is often necessary to overcome isoform redundancy, but it remains a technical challenge...