Wang J, Quake S (2014) RNA-guided endonuclease provides a therapeutic strategy to cure latent her- pesviridae infection. Proc Natl Acad Sci USA 111: 13157-13162. doi: 10.1073/pnas.1410785111 PMID: 25157128J.B. Wang, S.R. Quake, RNA-guided endonuclease provides a therap...
The biological role(s) of the RNA-guided endonuclease activity of Fzs remains unknown. In the case of TnpB, it seems to help TnpA-mediated transposition of the IS200/IS605 insertion sequences4,6,15. After TnpA-mediated peel-and-paste insertion, a TnpB-mediated double-strand break at the...
2023年6月28日,张锋团队在Nature期刊发表了题为:Fanzor is a eukaryotic programmable RNA-guided endonuclease 的研究论文 【1】 。 研究团队在真核生物中发现了第一个RNA引导的DNA切割酶——Fanzor,更重要的是,这种新型CRISPR样系统,可以在重编程后实现对人类基因组的编辑。 此外,相比CRISPR-Cas系统,Fanzor系统...
6 Jinek,M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J.A., and Charpentier,E.(2012) A programmable dual-RNA-guided DNA endonuclease in adaptivebacterial immunity. Science 337:816-821. DOI: 10.1126/science.1225829.
[7] Martin Jinek et al., (2012), A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity, Science, DOI: 10.1126/science.1225829 [8] ladstone Investigator Jennifer Doudna Wins Nobel Prize in Chemistry. Retrieved December 1, 2023, from https://gladstone.org/news/gladstone...
6 Jinek,M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J.A., and Charpentier,E.(2012) A programmable dual-RNA-guided DNA endonuclease in adaptivebacterial immunity.Science337:816-821. DOI: 10.1126/science.1225829. ・IP 属地北京...
1 Karvelis, T.et al.Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease.Nature599, 692-696, doi:10.1038/s41586-021-04058-1 (2021). 2 Altae-Tran, H.et al.The widespread IS200/IS605 transp...
比如，哈佛大学和麻省理工学院博德研究所张锋团队于2023年6月在Nature发表了题为“Fanzor is a eukaryotic programmable RNA-guided endonuclease”的突破性研究，为基因编辑增添了新的工具。该研究团队首次在真核生物中发现了一种名为Fanzor蛋白的RNA引导的DNA切割酶，这种新型CRISPR样系统能够在重编程后实现对人类基因...
比如,哈佛大学和麻省理工学院博德研究所张锋团队于2023年6月在Nature发表了题为“Fanzor is a eukaryotic programmable RNA-guided endonuclease”的突破性研究,为基因编辑增添了新的工具。该研究团队首次在真核生物中发现了一种名为Fanzor蛋白的RNA引导的DNA切割酶,这种新型CRISPR样系统能够在重编程后实现对人类基因组...
18. Zetsche B, Gootenberg JS, Abudayyeh OO, Slaymaker IM, Makarova KS, Essletzbichler P, Volz SE, Joung J, van der Oost J, Regev A, Koonin EV, Zhang F. Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system. Cell. 2015 Oct 22;163(3):759-71. doi: 10.1016...