The inhibition of proteins synthesis by an antisense RNA-tRNA complex which is capable of inhibiting translation is described. Under certain conditions, growth of organisms is inhibited by inhibition of non- specific translation by an antisense RNA construct to a tRNA target. In vitro, cell-free ...
The inhibition of proteins synthesis by an antisense RNA-tRNA complex which is capable of inhibiting translation is described. Under certain conditions, growth of organisms is inhibited by inhibition of non-specific translation by an antisense RNA construct to a tRNA target. In vitro, cell-free inh...
Oligonucleotide-mediated proximity-interactome MAPping (O-MAP) enables precise multiomic characterization of biomolecular interaction networks at target RNAs. Distinct O-MAP workflows reveal RNA-adjacent proteins, transcripts and genomic loci. Ashley F. Tsue ...
Stress granules (SGs) are highly dynamic cytoplasmic membrane-less organelles that assemble when cells are challenged by stress. RNA molecules are sorted into SGs where they play important roles in maintaining the structural stability of SGs and regulati
Once the first rounds of translation and processing are complete, the synthesized polymerase (3Dpol), together with other virus products and host proteins, forms a membrane-associated complex. This uses the genomic-sense RNA as a template for producing negative-sense copies which in turn act as ...
One of the most frequently modeled organs of the human organism is the liver, a central organ for the maintenance of chemical homeostasis that participates in the synthesis of proteins and detoxification. The human hepatoma HepG2 cell line (ATCC HB-8065) has been widely used as an in vitro ...
proteins have been found in mammalian genomes. These include ADAR1, which has two subtypes (ADAR1p110 and ADAR1p150), ADAR2 (ADARB1), and ADAR3 (ADARB2) [4,9]. Among these proteins, ADAR1 and ADAR2 are believed to be active, while ADAR3 functions as an inhibitor of A-to-I ...
RNA editing is a process that results in the synthesis of proteins that are not directly encoded in the genome. One type of RNA editing involves the modification of individual adenosine bases to inosine in RNA by ADAR enzymes (adenosine deaminases acting on RNA) [1, 2]. Because inosine acts...
(nuclear degradation) orspacer fragments, for example. The duration of lifetimes of mRNAs must be closely regulated, although the story of how this occurs may not be complete. Obviously, those RNA molecules that exhibit defects from improper processing, folding, or assembly with proteins are ...
Cryo-electron microscopy structures of intermediates formed during the degradation of the 30S ribosomal unit shed light on how the 3′ to 5′ exonuclease ribonuclease R controls the ribosomal degradation process. Lyudmila Dimitrova-Paternoga ,Sergo Kasvandik ...