The codon chart outlines the various codon combinations and their corresponding amino acids. To use the codon chart, for example, if the first codon position contains uracil (U), the second contains adenine (A), and the third contains cytosine (C), the resulting codon, UAC, represents the a...
2C). UPR program was characterized by key genes regulating protein folding and endoplasmic reticulum (ER) stress, and metabolic-associated program was featured by high expression of metabolic genes involved in glycolysis and amino acids metabolism (Fig. 2C and Additional file 1: Table S2). ...
Mutations of Basic Amino Acids of MCp7 of Human Immunodeficiency Virus Type 1 Affect RNA Binding In Vitro. J. Virol. 1996, 70, 771–777. [Google Scholar] [CrossRef] [Green Version] Zhang, Y.; Barklis, E. Nucleocapsid Protein Effects on the Specificity of Retrovirus RNA Encapsidation. J...
Nucleic Acids Res. 2017;45:9640–53. Article PubMed PubMed Central CAS Google Scholar Folco EG, Lee CS, Dufu K, Yamazaki T, Reed R. The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export. PLoS One. 2012;7:e43804...
(R) amino acids) and heterogeneous nuclear ribonucleoproteins (hnRNPs) interact with the splicing enhancers and splicing silencers coded in the transcript to permit alternative splicing4,5. Viral protein Rev binds to the Rev Response Element (RRE) of the transcript. This RNA-protein interaction ...
Most of the alternative TSSs, while not causing a frame shift, induced N-terminal truncation with different lengths up to 500 amino acids (Fig. 2d), which would lead to losses of N-terminal subcellular localization signals or protein domains based on predictions (Supplementary Data 16, 17). ...
By comparing amino acid sequences of the METTL3 MTase domain across different species,17 we located highly conserved residues within amino acids 380–500 of METTL3 (Figure 3D). We hypothesized that certain specific residues within the MTase domain may be vital for METTL3 function. To test this...
Gene expression is regulated at both transcriptional and posttranscriptional levels. Foreign genetic elements have evolved to integrate their expression systems into the host regulatory network. Transcription of AT-rich foreign genes is globally silenced by chromosomal nucleoid proteins such as H-NS. Simil...
DNA,RNA,Protein遗传物质 DNA,RNAandProtein HowtheInformationinDNAIsUsedtoBuildaProtein InformationFlowFromDNA Replication (priortonucleardivision)Gene:sequenceofDNAthatcodesforaprotein DNAtranscriptionRNAtranslation Protein (maintaincellmetabolismandsupportgrowth)DNAandRNAStructure DNA PrimaryStructureSecondaryStructure...
the frequency of specific amino acids sequences in known peptides. First, translated sequences generated by different reading frames are filtered based on length based on the theory that the ‘true’ translation will result in a long amino acid sequence. If there are multiple amino acid sequence...