Richter syndrome (RS) is defined as the transformation of chronic lymphocytic leukemia (CLL) to a more aggressive B-cell lymphoma, most commonly diffuse large B-cell lymphoma. Approximately 5-10% of CLL patients develop this complication during long-term follow-up. Traditional risk factors for ...
Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total...
1:24 | We also screened individuals for monoclonal B-cell lymphocytosis, or which is the precursor to CLL. We wanted to see if this score would also help predict individuals with this precursor condition if they progress to having chronic lymphocytic leukemia. This precursor condition is very co...
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphom... SI Berndt,CF Skibola,V Joseph,... - 《Nature Genet...
Risk Factors for Musculoskeletal Symptoms in 5-20 Year Survivors Who Received Myeloablative Hematopoietic Cell Transplant (HCT)Chronic lymphocytic leukemia (CLLAllogeneic transplantationAutologous transplantationCellular therapyHematopoietic stem cell transplantation (HSCT) recipients are at risk for varicella-zoster...
Susan L. SlagerClive S. ZentTaylor & FrancisLeukemia & LymphomaHallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working...
at doses as low as 10–15 mGy for NHL as a whole and for mature B cell neoplasms, the largest subgroup. A dose-dependent increase in RR was also seen for leukemia excluding chronic lymphocytic leukemia (CLL) in an analysis using previous classification for comparison with published ...
The incidence and prognostic factors for chronic graft-versus-host disease (cGVHD) were evaluated for 255 Japanese patients who survived more than 100 days after bone marrow transplantation, and of whom 119 (47%) developed cGVHD. Prior acute GVHD (grade 2-4) and use of an unrelated donor wer...
MDS indicates myelodysplastic syndromes; MPN, myeloproliferative neoplasms; CLL, chronic lymphocytic leukemia; CMV, cytomegalovirus; TNC, total nucleated cells. Data presented are n (%), unless otherwise indicated. ∗ Includes acute myeloid leukemia, acute lymphoblastic leukemia, and chronic myeloid leuke...
to theBAK1promoter and a strong negative association with expression suggests decreasedBAK1promotes ALL leukaemogenesis. Notably, the 6p21 region is also pleiotropic, influencing chronic lymphocytic leukaemia (CLL) and testicular cancer risk. Moreover, the strongest association for both CLL and ALL is...