Long-term event-free survival (EFS) of children with acute lymphocytic leukemia (ALL) has improved from 5% in 1965 to 65%–70% today [1]. These results, achieved by an increased intensity of treatment, have been accompanied by an increased incidence of acute (myelosuppression, infection) and...
Acute myeloid leukemia occurs when there are mutations in the DNA of the cells that normally produce some types of white blood cells. They grow out of control and crowd out normal cells in the bone marrow. Risk factors include age, sex, and exposure to radiation or chemotherapy. Some genetic...
MDS indicates myelodysplastic syndromes; MPN, myeloproliferative neoplasms; CLL, chronic lymphocytic leukemia; CMV, cytomegalovirus; TNC, total nucleated cells. Data presented are n (%), unless otherwise indicated. ∗ Includes acute myeloid leukemia, acute lymphoblastic leukemia, and chronic myeloid leuke...
Risk factors may have changed in this interval as transplant-related techniques have evolved.Acute GVHD risk factors were analyzed in 1,960 adults after HLA-identical sibling myeloablative transplant for acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), or chronic myeloid leukemia (CML...
E. et al. A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Nat Genet 46, 56–60 (2014). 16. The United Kingdom Childhood Cancer Study: objectives, materials and methods. UK Childhood Cancer Study Investigators. Br J Cancer 82, 1073–102...
Objective To investigate the indoor and outdoor environmental risk factors for childhood acute leukemia. Methods From September 2007 to August 2008,115 children aged 0 to 15 years with newly-onset acute leukemia were enrolled,among whom 87 were diagnosed as acute lymphocytic leukemia and the other ...
Genetic predisposition to B-cell acute lymphoblastic leukemia at 14q11.2 is mediated by aCEBPEpromoter polymorphism ArticleOpen access06 July 2018 Introduction Acute lymphoblastic leukaemia (ALL) is the most common paediatric cancer with B-cell precursor ALL (B-ALL) accounting for ~85% of the cases...
Percentages refer to non-missing values; acute myeloid leukemia (AML); acute lymphocytic leukemia (ALL); chronic lymphoid leukemia (CLL); chronic myeloid leukemia (CML); chronic myelomonocytic leukemia (CMML); cancer of unknown primary (CUP); myelodysplatic syndrome (MDS); neuroendocrine tumor (...
The clinical and pharmacokinetic risk factors for toxicity after high-dose methotrexate (MTX) in children with acute lymphoblastic leukemia were evaluated ... C Rask,F Albertioni - 《Acta Oncologica》 被引量: 177发表: 1998年 New Therapeutic Strategies in Acute Lymphoblastic Leukemia While cure rates...
In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results ...