产品名称:RISC-loading complex subunit TARBP2 ELISA Kit 检测范围:0.312-20 ng/mL. 保存条件:2-8℃低温保存 保质期:6个月,所有试剂盒均提供批次。 试剂盒成分:酶标板,试剂,标准品等。 选型: 产品规格:96T/48T 96T指可以做94个标本-2个标准对照-84个样本 48T指可以做47个标本-1个标准对照-42个样本 标...
(2009) Structural insights into RNA processing by the human RISC-loading complex. Nat. Struct. Mol. Biol. 16, 1148 -1153Wang HW, Noland C, Siridechadilok B, Taylor DW, Ma E, Felderer K, Doudna JA, Nogales E. Structural insights into RNA processing by the human RISC-loading complex. ...
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(2′-OMe) MePS2 on one nucleotide that significantly enhances potency and resistance to degradation for various siRNAs. We find enhanced potency stems from an unforeseen increase in siRNA loading to the RNA-induced silencing complex, likely due to the unique interaction mediated by 2′-OMe and ...
Alternatively, exogenous siRNA enters the pathway at this point, where it is recognized by the TRBP/PACT/Ago2 and Dicer complex, although its loading into RISC is not as efficient as that of hairpin pre-miRNAs or 27-mer Dicer substrate RNA duplexes (Elbashir et al., 2001, Gregory et al...
Berkeley Researchers Get First Look At Gene-Silencing Human RISC-Loading ComplexLynn Yarris
Domain comparison between human and Giardia Dicer proteins and sequence alignment between human DDX3X and the DExH/D domain of human dicer.(a) The sequences of human and Giardia Dicer are illustrated with their domains color-coded. The Ago2 binding motif within the human RNase IIIa domain ...
The present invention provides double stranded compositions wherein one of the strands is useful in, for example, influencing the preferential loading the opposite strand into the RISC (or cleavage) complex. In particular, the present invention provides oligomeric compounds that comprise chemical ...
2′-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity. Nature communications. 2014; 5 :3459. doi: 10.1038/ncomms4459. [ Cross Ref ]Sherry Y., WuXianbin, YangKshipra M., GharpureHiroto, HatakeyamaMartin, EgliMichael H., ...
In flies, asymmetric loading of small RNA duplexes into Argonaute2-containing RNA-induced silencing complex (Ago2-RISC) requires Dicer-2/R2D2 heterodimer, which acts as a protein sensor for the thermodynamic stabilities of the ends of small RNA duplexes. However, the ...