产品名称:RISC-loading complex subunit TARBP2 ELISA Kit 检测范围:0.312-20 ng/mL. 保存条件:2-8℃低温保存 保质期:6个月,所有试剂盒均提供批次。 试剂盒成分:酶标板,试剂,标准品等。 选型: 产品规格:96T/48T 96T指可以做94个标本-2个标准对照-84个样本 48T指可以做47个标本-1个标准
Domain comparison between human and Giardia Dicer proteins and sequence alignment between human DDX3X and the DExH/D domain of human dicer.(a) The sequences of human and Giardia Dicer are illustrated with their domains color-coded. The Ago2 binding motif within the human RNase IIIa domain ...
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Coordinates of the complex between a 9 mer siRNA and the PAZ domain from human Argonaute eIF2c1 were retrieved from the Protein Data Bank (http://www.rcsb.org; PDB ID code 1si2 (ref.29)). The programme UCSF Chimera51was used to convert the sequence of the last four nucleotides in the...
Alternatively, exogenous siRNA enters the pathway at this point, where it is recognized by the TRBP/PACT/Ago2 and Dicer complex, although its loading into RISC is not as efficient as that of hairpin pre-miRNAs or 27-mer Dicer substrate RNA duplexes (Elbashir et al., 2001, Gregory et al...
Berkeley Researchers Get First Look At Gene-Silencing Human RISC-Loading ComplexLynn Yarris
The present invention provides double stranded compositions wherein one of the strands is useful in, for example, influencing the preferential loading the opposite strand into the RISC (or cleavage) complex. In particular, the present invention provides oligomeric compounds that comprise chemical ...
2′-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity. Nature communications. 2014; 5 :3459. doi: 10.1038/ncomms4459. [ Cross Ref ]S.Y. Wu, X. Yang, K.M. Gharpure, H. Hatakeyama, M. Egli, M.H. McGuire, A.S. ...
The Integrator complex regulates microRNA abundance through RISC loadingdoi:10.1101/2021.09.21.461113Nina KirsteinSadat DokaneheifardPradeep Reddy CingaramMonica Guiselle ValenciaFelipe BeckedorffHelena Gomes Dos SantosEzra BlumenthalMina Masoumeh Tayari
Using biochemical tools to study the nature of the complex, our results demonstrate that the primary siRNA-binding protein in the whole cell extracts is Dicer. We find that Dicer is capable of discriminating highly functional versus poorly functional siRNAs by recognizing the presence of...