为探究草酸性肾病的发病机制,许艳芳教授团队构建了草酸盐诱导的急性肾损伤小鼠模型,发现敲除坏死样凋亡的核心信号分子ZBP1/RIPK3/MLKL能显著逆转小鼠肾脏损伤。在机制上,作者发现草酸钙刺激肾小管上皮细胞诱导氧化应激致线粒体损伤释放Z-m...
RIPK3 knockout inhibits STING signaling by intensifying STING autophagy. In contrast, MLKL regulates the STING pathway bidirectionally. MLKL deficiency enhances STING signaling, whereas suppression of MLKL-mediated pore formation restricts STING signaling. Mechanistically, upon abrogating the pro-necropto...
Necroptosis predominates functionally over apoptosis in the pathophysiology of renal ischemia-reperfusion injury (IRI). Inhibition of the core components of the necroptotic pathway—receptor-interacting protein kinase 1 (RIPK1), RIPK3 or mixed lineage ki
引用格式:彭伟,朱立国,尹逊路,罗杰,杨克新,冯敏山,于杰,梁龙,李玲慧,展嘉文,韩涛,罗明义,张典.基于 RIPK1/RIPK3/MLKL 信号通路探讨补肾活血方对兔椎间盘退变的影响[J].中国中医药信息杂志,2025,32(2):71-77. DOI:10.19879/j...
新加肾元方调控ＲＩＰＫ１/ＲＩＰＫ３/ＭＬＫＬ通路对高糖诱导的糖尿病 肾病肾小球足细胞损伤的影响 郑㊀玲ꎬ㊀陈㊀立ꎬ㊀王㊀月 (湖北文理学院附属医院襄阳市中心医院ꎬ㊀湖北㊀襄阳㊀４４１０２１)ʌ摘㊀要ɔ目的:探讨新加肾元方对高糖诱导的糖尿病肾病(ｄｉａｂｅｔｉｃｎｅｐｈｒｏｐａ...
MlklorRipk3, in mice. Our results show that the absence ofMlklorRipk3reduced liver inflammaging and age-associated MASLD pathology; however, the absence of these proteins had differential effects on lifespan and metabolic health. Additionally, the absence ofMlklorRipk3affected various cellular ...
Caspase-8 is an initiator of death receptor-induced apoptosis and an inhibitor of RIPK3-MLKL-dependent necroptosis. In addition, caspase-8 has been implicated in diseases such as lymphoproliferation, immunodeficiency, and autoimmunity in humans. Although
Necroptosis is regulated by three key proteins: receptor-interacting serine/threonine-protein kinase (RIPK)-1, RIPK3, and mixed-lineage kinase domain–like protein (MLKL). Here, we found that marked steatosis of the liver was induced when a Western diet was given in mice; steatosis was ...
RIPK1-RIPK3-MLKL-associated necroptosis drives Leishmania infantum killing in neutrophils 来自 Semantic Scholar 喜欢 0 阅读量: 74 作者:LA Barbosa,PP Fiuza,LJ Borges,FA Rolim,MB Andrade,NF Luz,QC Graziele,JB Lima,RP Almeida,FK Chan 摘要: Background Infections with parasites of the Leishmania ...
研究表明,程序性细胞坏死的机制是RIPK1和RIPK3形成复合体并激活MLKL,MLKL形成三聚体后定位在细胞膜上并导致细胞膜破裂,内容物流出,诱发细胞周围的炎症反应,并引起... 张浩,缪震元,张万年,... - 《中国药物化学杂志》 被引量: 0发表: 2019年 Taurine attenuates valproic acid-induced hepatotoxicity via modulation...