SAP-12 markedly decreased RIPK3- and MLKL-dependent necroptosis in ischemic brains. Of importance, SAP-12 had a much greater potency and broader effective dose range than the full length secreted AATF in vivo.Conclusions: SAP-12 can be targeted to the brain parenchyma following intraperitoneal ...
Ripk1 is known to act as a physiological negative regulator of both Caspase-8-dependent apoptosis and Ripk3/Mlkl-dependent necroptosis. We found that the absence of Ripk1 in neutrophils in Ptpn6∆PMN Ripk1∆PMN mice resulted in heightened sensitivity of neutrophils to cell death and ...
Here, we investigated the mechanisms controlling IL-1α/β release specifically from neutrophils (Ptpn6ΔPMN) by inhibiting Caspase-8-dependent apoptosis and Ripk1/Ripk3/Mlkl-regulated necroptosis. Loss of Ripk1 from neutrophils accelerated disease onset, whereas combined deletion of caspase-8 and ...
Initiation of necroptosis has been considered as a promising strategy for anticancer therapies, especially for eradicating apoptosis-resistant malignant cells. Jujubisode B is a natural saponins extracted from the seeds of Zizyphi Spinosi Semen, and possesses multiple pharmacological activities, including ...
Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis. Cell Death Dis 2014 ; 5:e1004; PMID: 24434512 ; http://dx.doi.org/ 10.1038/cddis.2013.531Remijsen Q., Goossens V., Grootjans S., Van den Haute C., Vanlangen...