作用机制 The mode of action of riluzole is unknown. Its pharmacological properties include the following, some of which may be related to its effect: 1) an inhibitory effect on glutamate release (activation of glutamate reuptake), 2) inactivation of voltage-dependent sodium channels, and 3) abil...
The effects of 0.1–100 μ m riluzole, a neuroprotective agent with anticonvulsant properties, were studied on neurons from rat brain cortex. Patch‐clamp whole‐cell recordings in voltage‐clamp mode were performed on thin slices to examine the effects of the drug on a noninactivating (...
Docking analysis has been carried out to elucidate how the introduction of substituents at the C-4 position could affect the binding mode with the target protein. In addition, we have developed the first general-purpose NIFPTML model for the prediction of neuroprotective compounds that considers ...
These results suggest that riluzole and gabapentin enhance Na+-glutamate co-transport through glutamate transporters, induce subsequent Ca2 + influx via the reverse mode of Na+/Ca2 + exchange, and thereby facilitate Ca2 +-dependent glutamate release by glutamate in astrocytes. The present ...