Doble A. The pharmacology and mechanism of action of riluzole. Neurology. 1996; 47 :S233–241.Doble A. The pharmacology and mechanism of action of riluzole. Neurology. 1996; 47 (6) Suppl. 4:S233–S241.Doble A. The pharmacology and mechanism of action of riluzole. Neurology. 1996; 47...
Mechanism of action The neuroprotective effects of riluzole principally derive from sodium channel blockade and modulation of glutamatergic excitotoxicity.109 SCI induces aberrant upregulation of neuronal voltage-gated Na+ channels107 leading to dysregulated osmotic gradients, acidosis (through disrupted hydrogen...
12.1 Mechanism of Action The mechanism by which riluzole exerts its therapeutic effects in patients with ALS is unknown. 12.2 Pharmacodynamics The clinical pharmacodynamics of riluzole has not been determined in humans. 12.3 Pharmacokinetics Table 2 displays the pharmacokinetic parameters of riluzole. Speci...
(1996), The pharmacology and mechanism of action of riluzole; Neurology 47 S233 5) Pittenger et al. (2008), Riluzole in the treatment of mood and anxiety disorders; CNS Drugs 22 761 6) Namkoong et al. (2007), Metabotropic glutamate receptor 1 and glutamate signaling in human melanoma; ...
with a potential impact on dependency for daily living functions, and on quality of life," comments Ristori. "The findings confirm our previous results, in the context of a virtual absence of therapy for the inherited forms of cerebellar ataxia." The mechanism of action of riluzole in patie...
Define Riluzole. Riluzole synonyms, Riluzole pronunciation, Riluzole translation, English dictionary definition of Riluzole. n. Abbr. ALS A chronic, progressive disease marked by gradual degeneration of the nerve cells in the spinal cord that control vol
In conclusion, riluzole is the first drug that has been shown to have an effect on survival in patients with ALS. Although the effect of riluzole was modest, it has allowed some insight into the pathogenesis of ALS from which future gains may be made. ...
摘要: Focuses on the use of riluzole in the treatment of amyotrophic lateral sclerosis (ALS). Etiology of ALS; Mechanism of action of riluzole; Effectiveness and benefits of the drug.年份: 2000 收藏 引用 批量引用 报错 分享 全部来源 求助全文 EBSCO ...
4 To clarify the mechanism of action of riluzole in patients with ALS, a post-hoc study by Ton Fang and colleagues published in The Lancet Neurology5 selectively explored the potential for riluzole to exert differential effects across disease stages. Analysing data from the original dose-ranging ...
asthenia, nausea, decreased lung function, hypertension and abdominal pain. While riluzole’s mechanism of action is not fully understood, in clinical studies it has been shown repeatedly to modulate glutamate neurotransmission by inhibiting both glutam...