In fact, the macroscopic extent of RV reverse remodeling (as measured by ventricular volumes, mass, and the tricuspid regurgitation fraction) was similar after early and late PVR strategies, although the measures did not completely normalize compared to controls. Microscopically, PR enhanced ...
hypotension and/or SBP < 100 mmHg; end-stage renal disease or estimated GFR < 30 mL/min/1.73 m2 (MDRD formula); serum potassium > 5.4 mmol/L at randomization; known history of hereditary or idiopathic angioedema or angioedema related to previous ACEI or ARB therapy; severe hepatic impairment...