Mitochondrial antiviral signaling protein (MAVS). LGP2 lacks an N-terminal CARD domain and is therefore unable to interact with IPS-1/MAVS. For this reason, LGP2 is thought to positively or negatively regulate RIG-I and MDA5 signaling rather than functioning as a signaling receptor on its ...
The RLG-I like receptor signaling pathway plays an important role in preventing the body from being infected by viruses. For this immune defense, the virus has some strategies to interfere with this process. After a virus infects cells, it often destroys the transduction of the RLR signaling ...
Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. Nat. Immunol. 11, 912–919 (2010). CAS PubMed PubMed Central Google Scholar Zhu, J. et al. Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor. Immunity 40...
RIG-I-like receptor signaling pathway Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helica...
Negative regulators of the RIG-I-like receptor signaling pathway. Eur J Immunol. 2017;47:615-28.Quicke, K.M., M.S. Diamond and M.S. Suthar, 2017. Negative regulators of the RIG‑I‑like receptor signaling pathway. Eur. J. ...
Interferons are important components of the host innate immune response. Type I IFNs (IFN-α, -β, -ε and -Ω) engage IFN-α/β receptor (IFNAR) and activate the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway, leading to the expression of interferon-...
During virus infection, multiple immune signaling pathways are triggered, both within the host cell and bystander cells of an infected tissue. These pathways act in concert to mediate innate antiviral immunity and to initiate the inflammatory response against infection. The RIG-I-like receptor (RLR)...
RIG-I like receptor(retinoic acid-induced gene I) is a kind of RNA helicase in cytoplasm,which belongs to the pattern recognition receptor of innate immunity,which can bind the pathogenic correlation molecular formula and RNA ligand to identify non-own viral RNA,activate the RIG-I signaling pat...
HSCARG Negatively Regulates the Cellular Antiviral RIG-I Like Receptor Signaling Pathway by Inhibiting TRAF3 Ubiquitination via Recruiting OTUB1. (2014). HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1. ......
Exploiting RIG-I-like receptor pathway for cancer immunotherapy Yangfu Jiang Hongying Zhang Hui Hua Journal of Hematology & Oncology (2023) The cellular and KSHV A-to-I RNA editome in primary effusion lymphoma and its role in the viral lifecycle Suba Rajendren Xiang Ye John Karijolich ...