side effects and supporting children over many months. The primary objective of this study is to evaluate if a 2-month regimen (including isoniazid (H), rifapentine (P), pyrazinamide (Z) and moxifloxacin (M)) is as safe and effective as a 4- to 6-month regimen (isoniazid, rifampicin (...
This prospective observational study aimed to compare the incidences of hepatitis and side effects between a new 2-month combination regimen of isoniazid, rifampin and pyrazinamid (2HRZ) plus excipient and the standard 3-month regimen of isoniazid and rifapentine (3HP) for LTBI treatment in Taiwan...
Isoniazid (INH) for six to nine months has 60% to 90% protective efficacy, but the treatment period is long, liver toxicity is a problem, and completion rates outside trials are only around 50%. Rifampicin or rifamycin-combination treatments are shorter and may result in higher completion ...
Preventive therapy of tuberculosis with rifapentine in immunocompetent and nude mice The effectiveness of intermittent administration of rifapentine (RPT), with or without isoniazid (INH), for preventive therapy of tuberculosis was evaluate... L Chapuis,B Ji,C Truffot-Pernot,... - 《American Journ...
isoniazidp450 cytochrome systempulmonary tuberculosisrifapentineSummary This chapter provides the basic characteristics, FDA-approved indication, side effects/toxicity, drug interactions, and dosing of the Priftin (Rifapentine). Rifapentine inhibits DNA-dependent RNA polymerase activity in susceptible cells. ...
The mechanisms of action and resistance, pharmacokinetic and pharmacodynamics, potential drug interactions and side effects are discussed. Expert commentary: Rifapentine in combination with isoniazid for twelve weeks is the best available option for treating latent TB in the majority of patients in the ...
Stennis NL, Burzynski JN, Herbert C, Nilsen D, Macaraig M. Treatment for Tuberculosis Infection With 3 Months of Isoniazid and Rifapentine in New York City Health Department Clinics. Clin Infect Dis 2016 Jan 01;62(1):53-59. [doi: 10.1093/cid/civ766] [Medline: 26338781]...
We assessed the uptake and completion of a 12-dose, weekly isoniazid鈥搑ifapentine (3HP) TPT regimen. Methods: Between February 2018 and March 2019 in Dhaka, community-based TPT using 3HP targeted household contacts of 883 confirmed drug-sensitive pulmonary TB patients. Adhering to World Health...