et al. Comparison of the pharmacokinetics and hepatotoxic effects of saporin and ricin A-chain immunotoxins on murine liver parenchymal cells. Cancer Res. 1988;48:7072-70783263899Google Scholar 70. Ramsden CS, Drayson MT, Bell EB. The toxicity, distribution and excretion of ricin holotoxin in...
Yet, currently synergistic AMP effects on cancer cells remain to be investigated. Although cytotoxicity strongly limits the clinical use of AMPs in the systemic treatment, the increasing understanding of the activities of the physiological agents as well as currently evolving synthetic “designer peptide...
Therefore, the only recommendation is to rid the body of the toxins as quickly as possible. Ricin and abrin poisoning is treated by giving victims the appropriate supportive medical care to minimize the effects of the poisoning. Cases of gastrointestinal exposure are the best managed by vigorous ...
There is no antidote for ricin poisoning, and medical treatment consists of supportive measures (such as breathing support, intravenous fluids, and medications to control blood pressure and seizures) to try to counteract or reduce the effects of the toxin on the body. Bacterial Infections 101 Revie...
Risk ofaggravating injury to the lining of the gastrointestinal (GI)tract must be considered.To minimize the effects of the poisoning and to keep thepatient stable, Ricin poisoning is treated through supportivetherapy. The types of supportive medical care would dependon several factors, such as ...
For more detailed information about effects of Ricin on livestock, see... "Poisonous Plants Page, Ricinus Communis, http://res.agr.ca./ Protection against Ricin There is currently no vaccine or prophylactic antitoxin available for human use, although immunization appears promising in animal models...
Human systemic effects by ingestion: convulsions or effect on seizure threshold, cyanosis, death, dehydration, diarrhea, headache, hypermotility, nausea or vomiting, other gastrointestinal effects, somnolence. Experimental reproductive effects. Mutation data reported. An eye irritant. Inhalation or ...
administration. Inhalation is the most potent route of entry, and oral ingestion is less toxic and may be nonlethal. RT is detected in tissue sections, body fluids, and nasal swabs of poisoned animals by enzyme-linked immunosorbent assay (ELISA). Treatment of intoxicated patients is very ...
chain alone is not toxic. In fact, manyedible plantssuch as barley synthesize A chain. The B-chain has been expressed in monkey COS-M6 cells with noadverse effects(Weston et al., 1994). A representation of the ricin protein based on X-ray crystallographic data is presented inFigure 27.4....
Once inside the cells, the vesicle containing the toxin is delivered via the retrograde transport pathway to the endoplasmic reticulum. The toxin finally reaches the cytoplasm from the endoplasmic reticulum by retro-translocation and imposes its effects on the ribosome substrate (6), which can ...