Effect of large ribosomal subunit proteins on ribosome biogenesis and cell cycleRibosome biogenesis and cell cycle are coordinated processes. Recent studies in mammalian cell lines have showed that ribosome biogenesis is linked to tumorgenesis, where mutation or depletion of ribosomal factors, leads ...
Jaskolowski, M. et al. Structural insights into the mechanism of mitoribosomal large subunit biogenesis.Mol. Cell79, 629–644.e4 (2020). ArticleCASGoogle Scholar Tobiasson, V. et al. Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit.EMBO J.40, e106292 (20...
The folding of ribosomal RNAs is central to the biogenesis of the mitoribosome and is a complex, stepwise process. Five recent cryo-EM studies detail the late steps of the folding and maturation of the human mitoribosomal large subunit RNA that forms the catalytic core of the ribosome: the ...
RNA modifications are widespread in biology and abundant in ribosomal RNA. However, the importance of these modifications is not well understood. We show that methylation of a single nucleotide, in the catalytic center of the large subunit, gates ribosom
The proline-rich antimicrobial designer peptide Api137 inhibits protein expression in bacteria by binding simultaneously to the ribosomal polypeptide exit tunnel and the release factor (RF), depleting the cellular RF pool and leading to ribosomal arrest
(Table3). The evolutionary conservation ofRpLP0-likeandRpL24-likesuggests they have important cellular functions. Indeed, the yeast ortholog of RpL24-like is found in pre-ribosomal complexes where it is thought to function in large subunit biogenesis [83]. It remains to be seen whether the ...
Research2MeVt0oaa0lrul7y.mgoeld8, Issue 10, Article R216 Open Access The ribosomal protein genes and Minute loci of Drosophila melanogaster Steven J Marygold*, John Roote†, Gunter Reuter‡, Andrew Lambertsson§, Michael Ashburner†, Gillian H Millburn†, Paul M Harrison¶, Zhan ...
(iNo) to stratify qualitatively and quantitatively nucleolar morphological alterations. We conclude that irrespective of their requirement for processing, the vast majority of r-proteins do not impact nucleolar structure or p53 levels. We found major contributors are all late-assembling large subunit r-...
The Saccharomyces cerevisiae TIF6 gene encoding translation initiation factor 6 is required for 60S ribosomal subunit biogenesis. Eukaryotic translation initiation factor 6 (eIF6), a monomeric protein of about 26 kDa, can bind to the 60S ribosomal subunit and prevent its association w... U Basu,...
Altered mRNA translation in cells with ribosome biogenesis defects.aIn normal cells, functional mature ribosomes (80S) comprise the small (40S) subunit and the large (60S) subunit. The small subunit interacts with the anticodon-containing ends of complementary tRNAs so as to translate the codon in...