In the present study, human (h)iPSC-CMs were generated from iPSCs by including glycogen synthase kinase 3尾 and Wnt inhibitors in the basal culture media. The possible effect of Y27632, a ROCK inhibitor, on hiPSC-CMs was then investigated. hiPSC-CMs of high purity were harvested with >96...
Fasudil, a Rho-associated protein kinase inhibitor, attenuates traumatic retinal nerve injury in rabbits [J]. J Mol Neurosci, 2016, 58(1): 74-82.Song H, Gao D. Fasudil, a Rho-associated protein kinase inhibitor, at- tenuates retinal ischemia and reperfusion injury in rats [J]. Int J ...
the kinase activity of ROCKs by an autoinhibitory intramolecular fold if RhoA-GTP is not present. ROCK plays a role in a wide range of different cellular phenomena, as ROCK is a downstream effector protein of the small GTPase Rho, which is one of the major regulators of the cytoskeleton.
et al. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol 57, 976–983 (2000). 59. Tokushige, H. et al. Effects of topical administration of y-39983, a selective rho- associated protein kinase inhibitor, on ocular tissues in rabbits and ...
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Y-27632, a Rho-associated protein kinase inhibitor, attenuates neuronal cell death after transient retinal ischemia Purpose: Transient retinal ischemia induces the death of retinal neuronal cells. Postischemic damage is associated with the infiltration of leukocytes into... A Hirata,M Inatani,Y Inomat...
Nishio M, Fukunaga T, Sugimoto M, Ikesugi K, Sumi K, Hidaka H and Uji Y: The effect of the H-1152P, a potent Rho-associated coiled coil-formed protein kinase inhibitor, in rabbit normal and ocular hypertensive eyes. Curr Eye Res. 34:282–286. 2009. View Article : Google Scholar :...
The effects of melatonin and H-1152, a selective inhibitor of Rho-associated protein kinase (ROCK), on the migration of RKO cells were analyzed by anin vitrowound healing assay. The localization of zonula occludens-1 (ZO-1) and occludin were observed by immunofluorescence. Reverse transcription...
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR...
Moreover, DLC1 expression was negatively correlated with Rho-associated protein kinase (ROCK) expression in LNCaP cells. Importantly, this study showed that the ROCK inhibitor Y27632 restored the function of DLC1 in LNCaP cells and reduced the tumorigenicity of LNCaP cells in vivo. Conclusion Our...