Rho-associated protein kinase (ROCK) is involved in a wide range of fundamental cellular functions and serves significant roles in cardiac physiology. In the present study, human (h)iPSC-CMs were generated from iPSCs by including glycogen synthase kinase 3尾 and Wnt inhibitors in the basal ...
Rho-associated protein kinase AGC (PKA/ PKG/PKC) family of serine-threonine kinases. ROCKs (ROCK1 and ROCK2) occur in mammals, zebrafish, Xenopus,invertebrates and chicken. Human ROCK1 has a molecular mass of 158 kDa and is a major downstream effector of the small GTPase RhoA. Mammalian ...
Rho-associated coiled-coil-containing protein kinase (ROCK) inhibitors are serine/threonine kinases that act on small Rho GTPases and are involved in cytoskeleton organization, cell migration, and cell-cell adhesion (Riento and Ridley, 2003). Initially used to enhance the efficiency of culturing ...
OPEN SUBJECT AREAS: TRANSLATIONAL RESEARCH CELL BIOLOGY Received 21 August 2014 Accepted 23 February 2015 Published 16 March 2015 The effects of Rho-associated kinase inhibitor Y-27632 on primary human corneal endothelial cells propagated using a dual media approach Gary S. L. Peh1,2, Khadijah ...
Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility. Invest. Ophthalmol. Vis. Sci. 42, 137–144 (2001). CAS PubMed Google Scholar Goldhagen, B., Proia, A. D., Epstein, D. L. & Rao, P. V. Elevated levels of RhoA in the optic ...
To report the safety, efficacy, and long-term outcome in a case of Fuchs endothelial corneal dystrophy (FECD) treated by Rho-associated protein kinase (ROCK)-inhibitor eye drops in combination with removal of degenerated corneal endothelial cells (CECs) subsequent to transcorneal freezing. Observati...
Application of Rho-associated protein kinase (ROCK) inhibitor to human pluripotent stem cells Susceptibility of human pluripotent stem cells (hPSCs), such as human iPS and embryonic stem (ES) cells, to single-cell dissociation has been a large obsta... H Kurosawa - 《Journal of Bioscience & ...
Rho-associated protein kinase is an essential regulator of cytoskeletal dynamics during the process of neurite extension.However,whether Rho kinase regulates microtubule remodeling or the distribution of adhesive proteins to mediate neurite outgrowth remains unclear.By specifically modulating Rho kinase activity...
Rho-associated protein kinase (ROCK) inhibitor Y-27632 enhanced the survival of cryopreserved of human embryonic stem (ES) cells, and improved the ES colony formation. In this study, we used Y-27632 for porcine (Sus scrofa) induced pluripotent stem cells. 5 and 10μmol/L Y-27632...
Rho-Kinase inhibitor 1 is a Rho kinase (ROCK) inhibitor (Ki values of 30.5 and 3.9 nM for ROCK1 and ROCK2, respectively) extracted from US20090325960A1, compound 1.008. ChemeGen 作为优秀的抑制剂、激动剂及新型生命科学试剂的供应商,致力于为广大科研、商业实验室的科学研究者提供高品质的产品与技术...