Fasudil, a specific Rho-kinase inhibitor, alleviated epileptic seizures in the pilocarpine rat model of TLE. Furthermore, ROCK2 activated the Stat3 pathway in pilocarpine-treated epilepsy rats, and the spearman correlation method confirmed that ROCK2 is associated with Stat3 activation in TLE patients...
Rho-associated protein kinase 2 2.7.11.1 KIAA0619 p164 ROCK-2 Rho kinase 2 Rho-associated, coiled-coil-containing protein kinase 2 Rho-associated, coiled-coil-containing protein kinase II ROCK-II ROCK2 UniProtKB Entry O75116Swiss-Prot
Rho-associated protein kinase AGC (PKA/ PKG/PKC) family of serine-threonine kinases. ROCKs (ROCK1 and ROCK2) occur in mammals, zebrafish, Xenopus,invertebrates and chicken. Human ROCK1 has a molecular mass of 158 kDa and is a major downstream effector of the small GTPase RhoA. Mammalian ...
Rho-associated protein kinase AGC (PKA/ PKG/PKC) family of serine-threonine kinases. ROCKs (ROCK1 and ROCK2) occur in mammals, zebrafish, Xenopus,invertebrates and chicken. Human ROCK1 has a molecular mass of 158 kDa and is a major downstream effector of the small GTPase RhoA. Mammalian ...
3.3.2 Use of rho-kinase inhibitors Rho-associated coiled-coil-containing protein kinase (ROCK) inhibitors are serine/threonine kinases that act on small Rho GTPases and are involved in cytoskeleton organization, cell migration, and cell-cell adhesion (Riento and Ridley, 2003). Initially used to...
Objective: To investigate the protection by Rho kinase inhibitor (fasudil) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) and the role of Rho-associated coiled-coil-forming protein kinase 2 (ROCK2) in neutrophil transendothelial migration in the murine model. Material and Methods: Mice...
Rho-associated protein kinase is an essential regulator of cytoskeletal dynamics during the process of neurite extension.However,whether Rho kinase regulates microtubule remodeling or the distribution of adhesive proteins to mediate neurite outgrowth remains unclear.By specifically modulating Rho kinase activity...
Rho-kinase inhibitor can relieve adverse cardiac remodeling after myocardial infarction. The down-regulation of ROCK can reduce cardiac fibrosis11, and specific deletion of ROCK2 in fibroblasts can alleviate cardiac hypertrophy, fibrosis and diastolic dysfunction through inhibiting the production of ...
Application of Rho-associated protein kinase (ROCK) inhibitor to human pluripotent stem cells Susceptibility of human pluripotent stem cells (hPSCs), such as human iPS and embryonic stem (ES) cells, to single-cell dissociation has been a large obsta... H Kurosawa - 《Journal of Bioscience & ...
associatedcoiledcoilformingproteinkinase,ROCK)可提升肌球蛋白轻链 (myosinlightchain,MLC)的磷酸化水平,增加肌动-肌球蛋白的收缩力促使细胞 在ECM中的迁移。ROCK是Rho下游的重要效应分子,包括Rho激酶和p160ROCK2 个成员。活化的ROCK通过2条通路提升MLC的磷酸化水平,一方面ROCK磷酸化其 底物肌球蛋白轻链磷酸酶(myosin...