综述了Rho GTPase家族典型亚家族成员RhoA,Cdc42和Rac1在耳蜗毛细胞的表达以及这些小分子蛋白是如何参与耳蜗毛细胞纤毛束的形态发生和外毛细胞运动,并且这些小分子作为感音神经性耳聋治疗的药物靶点的研究现状。
View PDF Download full issue Search ScienceDirect FEBS Letters Volume 582, Issue 14, 18 June 2008, Pages 2093-2101MinireviewRho GTPases in cancer cell biology Edited by Christos Stournaras Author links open overlay panelFrancisco M. Vega, Anne J. RidleyShow more Share Cite...
The Rho GTPase RhoB has been proposed to be a tumor suppressor in cancer and is downregulated in various tumors including prostate. RhoB has different effects on cell migration depending on the cell type and conditions, but the molecular basis for this v
Abstract 2146: The Rho GTPase RhoE is a p53-regulated candidate tumor suppressor Rho family proteins are prominent members of the well-known Ras superfamily and are deeply involved in almost all the malignant behaviors of cancer. As Small GTPases, Rho proteins can cycle between active GTP-bound...
Rho A is a small GTPase protein. Rho kinases (Rho associated protein kinase, ROCK) are serine or threonine kinases that determine the calcium sensitivity in smooth muscle cells (see Fig. 8.9) and contribute to the regulation of a variety of functions including smooth muscle contraction, gene ex...
The Rho GTPases A, B and C proteins, members of the Rho family whose activity is regulated by GDP/GTP cycling, function in many cellular pathways controlling proliferation and have recently been implicated in tumorigenesis. Although overexpression of Rho
High RGPRG score was correlated with cell cycle, primary immunodeficiency, and higher TP53 mutation To determine the potential regulation pattern of the Rho GTPase signaling-related gene signature, we carried out a GSEA enrichment analysis and found that the two RGPRG score groups showed different ...
Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease. Oncogene 2014; 33: 4021–4035. CAS PubMed Google Scholar Vigil D, Cherfils J, Rossman KL, Der CJ . Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nat ...
skin cancer, developing fewer tumors, although the tumors that do form are more aggressive [141]. These results suggest that Rac proteins normally stimulate tumor cell proliferation but inhibit tumor dissemination. Rac1 could contribute to cancer cell proliferation via regulation of the cell cycle: ...
别名GAP; Gap1; GTPase activating protein; HsCYK 4; HsCYK4; ID GAP; KIAA1478; MgcRacGAP; Rac GTPase activating protein 1; RACGAP 1; RGAP1_HUMAN. Rho GTP酶激活蛋白GAP抗体可以满足客户的不同需求 1、提供多物种的多抗产品:包括兔、小鼠、山羊、鸡和鱼等物种 ...