综述了Rho GTPase家族典型亚家族成员RhoA,Cdc42和Rac1在耳蜗毛细胞的表达以及这些小分子蛋白是如何参与耳蜗毛细胞纤毛束的形态发生和外毛细胞运动,并且这些小分子作为感音神经性耳聋治疗的药物靶点的研究现状。
Share on Facebook rho Thesaurus Medical Legal Financial Acronyms Encyclopedia Wikipedia rho (rō) n. The 17th letter of the Greek alphabet. See Table atalphabet. [Greekrhō,of Phoenician origin; seerʔšinSemitic roots.] American Heritage® Dictionary of the English Language, Fifth Edition. ...
产品描述 ML141是Rho家族GTPase cdc42的一种有效的,选择性可逆非竞争性抑制剂,IC50为200nM。 信号通路 Cell Cycle 靶点 cdc42 - - - - IC50 200nM - - - - 体外研究 ML141通过诱导细胞死亡和抑制细胞分裂,增强TMX抑制细胞生长的能力。ML141也显著保护神经母细胞瘤免受二甲双胍诱导的凋亡损害。此外,...
This antiproliferative effect has been attributed to the ability of Rnd3 to antagonize RhoA by increasing p190 RhoGAP activity and to induce cell-cycle arrest at the G1 phase [119,120]. Each Rnd GTPase possesses a CAAX box that terminates with Met; as such, all Rnd proteins are farnesylated...
cycle between inactive GDP-bound and active GTP-bound conformations. Their interconversion is tightly regulated by three classes of proteins: (1) guanine nucleotide exchange factors (GEFs), which mediate activation by increasing the ratio of GDP/GTP exchange; (2) GTPase-activating proteins (GAPs) ...
skin cancer, developing fewer tumors, although the tumors that do form are more aggressive [141]. These results suggest that Rac proteins normally stimulate tumor cell proliferation but inhibit tumor dissemination. Rac1 could contribute to cancer cell proliferation via regulation of the cell cycle: ...
别名GAP; Gap1; GTPase activating protein; HsCYK 4; HsCYK4; ID GAP; KIAA1478; MgcRacGAP; Rac GTPase activating protein 1; RACGAP 1; RGAP1_HUMAN. Rho GTP酶激活蛋白GAP抗体可以满足客户的不同需求 1、提供多物种的多抗产品:包括兔、小鼠、山羊、鸡和鱼等物种 ...
Most Rho family GTPases cycle between an active GTP-bound state and an inactive GDP-bound state. Their activation is controlled by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs), which activate or inactivate them respectively. In their active GTP-bound form, Rho...
溶液配制5mg加入1.23ml DMSO,或者每4.07mg加入1ml DMSO,配制成10mM溶液。SC6565-10mM用DMSO配制。 生物信息: 产品描述ML141是Rho家族GTPase cdc42的一种有效的,选择性可逆非竞争性抑制剂,IC50为200nM。 信号通路Cell Cycle 靶点cdc42--- IC50200nM--- 体外...
These GTPase cycle through the active, GTP-bound and inactive, GDP-bound forms, and upon activation, interact with and stimulate different downstream kinases and accessory proteins. While actions of all three major members of this family, namely Rho, Rac1, and Cdc42, have been implicated in th...