综述了Rho GTPase家族典型亚家族成员RhoA,Cdc42和Rac1在耳蜗毛细胞的表达以及这些小分子蛋白是如何参与耳蜗毛细胞纤毛束的形态发生和外毛细胞运动,并且这些小分子作为感音神经性耳聋治疗的药物靶点的研究现状。
Abstract 2146: The Rho GTPase RhoE is a p53-regulated candidate tumor suppressor Rho family proteins are prominent members of the well-known Ras superfamily and are deeply involved in almost all the malignant behaviors of cancer. As Small GTPases, Rho proteins can cycle between active GTP-bound...
Villalonga P, Ridley AJ. 2006. Rho GTPases and cell cycle control. Growth FactVillalonga P, Ridley AJ. Rho GTPases and cell cycle control. Growth Factors 2006; 24: 159-164.Villalonga P, Ridley AJ. Rho GTPases and cell cycle control. Growth Factors. 2006; 24:159-164. [PubMed: ...
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, an...
产品描述 ML141是Rho家族GTPase cdc42的一种有效的,选择性可逆非竞争性抑制剂,IC50为200nM。 信号通路 Cell Cycle 靶点 cdc42 - - - - IC50 200nM - - - - 体外研究 ML141通过诱导细胞死亡和抑制细胞分裂,增强TMX抑制细胞生长的能力。ML141也显著保护神经母细胞瘤免受二甲双胍诱导的凋亡损害。此外,...
Share on Facebook rho Thesaurus Medical Legal Financial Acronyms Encyclopedia Wikipedia rho (rō) n. The 17th letter of the Greek alphabet. See Table atalphabet. [Greekrhō,of Phoenician origin; seerʔšinSemitic roots.] American Heritage® Dictionary of the English Language, Fifth Edition. ...
产品描述 ML141是Rho家族GTPase cdc42的一种有效的,选择性可逆非竞争性抑制剂,IC50为200nM。 信号通路 Cell Cycle 靶点 cdc42 - - - - IC50 200nM - - - - 体外研究 ML141通过诱导细胞死亡和抑制细胞分裂,增强TMX抑制细胞生长的能力。ML141也显著保护神经母细胞瘤免受二甲双胍诱导的凋亡损害。此外,...
Hohhot010021,China)AbstractSmallRhoGTPaseproteinfamilyisamemberoftheRassuperfamily.ThehumanRhofamilyofsmal1GTPaseiScomprisedof20members,ofwhichRhoA,Rac1andCdc42arebest.studied.SmallRhoGTPasesareinvolvedinmanyimportantbiologicalprocesses,suchascellcytoskeletonregulation,cellmigration,cellproliferationandcellcycle...
Theconclusion is clear: Cdc42p is not needed for cell growth orprotrusion formation per se, but it is needed for these processes toGAPGEFRho-GDPRho-GDPGDIGDPGTPEffectorsRho-GTPPlasma membranePiFigure 1 The Rho GTPase cycle. Twenty mammalian Rho GTPases have beendescribed: Rho (three isoforms...
is by Regulation of Rho GTPase activity: in [21]);Rho GTPases cycle between inactive GDP-bound and activ^oweverj this GTP-bound conformations; the activation state is activity can be controlled by GAPs (reviewed in [11]), GEFs [12, 13], andaj-|-erecj to drive plasma membrane, which...