Rho-associated kinase(ROCK) is a key regulatory protein involved in inflammatory secretion in microglia in the central nervous system.Our previous studies showed that ROCK inhibition enhances phagocytic activity in microglia through the extracellular signal-regulated kinase(ERK) signaling pathway,but its ...
Y-27632 (5 mg/kg, 10 mg/kg)处理实验组小鼠,与对照组(生理盐水组)相比,Y-27632明显延长肌肉痉挛的发作时间和阵挛性惊厥发作时间。[2] 参考文献 Xue ZW, et al. Rho-associated coiled kinase inhibitor Y-27632 promotes neuronal-like differentiation of adult human adipose tissue-derived stem cells. Chi...
关键词Y-27632,猪诱导多能干细胞(iPS细胞),Rho相关蛋白激酶(ROCK),冻存,凋亡 EffectedofRho-associatedProteinKinaseInhibitorY-27632on ImprovingtheCryopreservedSurvivalandPassageofPorcine(Susscrofa) InducedPluripotentStemCells CHENGDeGAOXingLIZhen-ZhenGAOYiLIUYa-JunBAOJian-ChangWANGHua-Yan ...
The Integrin-linked Kinase Regulates Cell Morphology and Motility in a Rho-associated Kinase-dependent Manner Suppression of cell spreading and motility of WT ILK U2OS cells could be rescued by treatment with the Rho-associated kinase (ROCK) inhibitor Y-27632 or... WAKM Khyrul,DP Lalonde,MC ...
OPEN SUBJECT AREAS: TRANSLATIONAL RESEARCH CELL BIOLOGY Received 21 August 2014 Accepted 23 February 2015 Published 16 March 2015 The effects of Rho-associated kinase inhibitor Y-27632 on primary human corneal endothelial cells propagated using a dual media approach Gary S. L. Peh1,2, Khadijah ...
Rho-kinase inhibitor Y-27632 and hypoxia synergistically enhance chondrocytic phenotype and modify S100 protein profiles in human chondrosarcoma cellsArticular chondrocytes are slowly dividing cells that tend to lose their cell type-specific phenotype and ability to produce structurally and functionally ...
Rho-associated kinase inhibitor (ROCK inhibitor, Y27632) was added into the ... HJ Chi,SY Choi,DY Chung 被引量: 0发表: 2010年 人類胚胎幹細胞與胰蛋白&;#37238;篩選之人類胚胎幹細胞亞群間基因表現差異 人類胚胎幹細胞(human embryonic stem cells, HES cells)的單細胞繼代存活率很低,目前繼代人類...
[5]Fu X.The effects of the Rho-kinase inhibitor Y-27632 on arachidonic acid-,GTP S-,and phorbol ester-induced Casensitization of smooth muscle[J].FEBS Lett,1998,440: 183-187. [6]Kimura K,Kaibuchi K.Regulation of myosin phosphatase by Rho and Rho-associated kinase(Rho-kinase)[J].Scien...
参考文献 for Y-27632 dihydrochloride 参考文献是支持产品生物活性的出版物。 Narumiyaet al(2000)Use and properties of ROCK-specific inhibitor Y-27632.Methods Enzymol.325273 PMID: 11036610 Uehataet al(1997)Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase.Nature389990 PMI...
Y-27632 ( 二盐酸盐) 主要用于干细胞研究领域的维持和分化。常用作3D生长矩阵组件; 也是脑类器官分化培养基的组成部分。是一种口服有效的, ATP 竞争性的 ROCK-I 和 ROCK-II 抑制剂,Ki 分别为 220 nM 和 300 nM。Y-27632 dihydrochloride 诱导凋亡 。Y-27632 dihydrochloride 通过上皮-间充质过渡样调节引发人...