rhIL-7-hyFc (efineptakin-alfa; NT-I7) is a potent T cell amplifier, comprised of two molecules of interleukin-7 (IL-7) fused to the hybrid Fc domain of IgD/IgG4 immunoglobulin. NT-I7 safely, significantly, and persistently increases the absolute lymphocyte counts (ALC) in humans in a...
7-hyFc with CAR T cells exhibited sustained B cell aplasia and were protected against tumor rechallenge. Functional studies and single-cell RNA-seq (scRNA-seq) reveal that rhIL-7-hyFc not only increases CAR T cell numbers but also improves T cell cytotoxicity and decreases exhaustion. ...
The study also simulated the positions of 14C labeling in rhIL-7-hyFc, identifying specific residues in the fragment of rhIL-7 portion, and provided the explanation of distinct analytes targeted by each method. Combining ELISA and AMS provided advantages by offering sensitivity and specificity for ...
TJ107/HyLeukin-7™ (Efineptakin alfa)是世界上第一个也是唯一一个长效改组人白蛋白羟基丁酸-7 (rhIL-7),它可以通过提高T淋巴蛋白的比同上及改善T蛋白功能来加强T淋巴蛋白血球分裂。该产品利用Genexine专利技术平台hyFc®开发取而代之长效生命体制剂。天境生命体已获得TJ107/ HyLeukin™在区临床深入研究开...
Hyleukin-7™以外位处1b或2期,针对几种乳癌的单一病人法或协同病人法的临床研究试验性之当年。 Papitrol是一种针对人突起流感病毒(HPV)特别疟疾的病人性DNA本品,以外将要与默沙东Keytruda(可摩托罗拉)协同用于更早复发性宫颈癌的2期试验性。 Genexine已完成HyTropin(长效人类荷尔蒙,hGH-hyFc)针对成年人荷尔蒙溶血...
TJ107/HyLeukin-7™ (Efineptakin alfa)是世界性上第一个也是唯一一个长效合并人红细胞内组胺-7 (rhIL-7),它可以通过增加T细胞内则会的数目及改善T细胞内系统来促进T细胞内则会增生。该产品来进行Genexine专利高效率平台hyFc®共同完成开发的长效海洋生物制剂。天境海洋生物已拿到TJ107/ HyLeukin™在区临床...
根据研究团队近日发表在Cell Reports Medicine上的论文介绍,他们利用了一种与白细胞介素-7(IL-7)融合的重组蛋白rhIL-7-hyFc作为催化剂,与双特异性抗体进行配合,提高双特异性T细胞结合器的抗肿瘤功效。 由于IL-7在T细胞发育、分化和存活中起着至关重要的作用,使用重组蛋白rhIL-7-hyFc可以增加T细胞的数量,并且重组...