HOTAIR-modulated changes in SF gene expression and function were associated with changes betweeen hand and knee arthritis in RA, suggesting that HOTAIR may shape the phenotype of arthritis in lower extremity joints. By showing that an embryonically imprinted, site-specific factor can regulate ...
Introduction In the past 20 years, the availability of tumor necrosis factor inhibitors (TNFis) and other biologic disease-modifying antirheumatic drugs (bDMARDs) has transformed treatment for patients with rheumatoid arthritis (RA). More recently, targeted synthetic DMARDs (tsDMARDs), including janus...