Kotani N., Nina Wang N., Dhillon P.K., Arndorfer S., Chanu P. A model based approach to infer overall survival (OS) in hormone receptor positive (HR+) human epidermal growth factor receptor 2 negative (HER2-) metastatic breast cancer (HR+/HER2- mBC). Population Approach Group Europe ...
17.A Mechanistic, Multiscale Mathematical Model of Immunogenicity for Therapeutic Proteins: Part 1—Theoretical Model 机译:治疗性蛋白质免疫原性的机械化,多尺度数学模型:第1部分-理论模型 作者:TP Hickling;X Chen 期刊名称:《CPT: Pharmacometrics & Systems Pharmacology》 | 2014年第9期 18.Incorporating ...
The endosomal distribution of TLR7 and TLR8 allows them to scan for the presence of microbial RNA in the phagocytic cargo. Their activation leads to NF-κB-, AP1-, and interferon regulatory factor (IRF)-mediated production of type I interferons (IFN-α/β) and pro-inflammatory cytokines [2...
Kotani N., Nina Wang N., Dhillon P.K., Arndorfer S., Chanu P. A model based approach to infer overall survival (OS) in hormone receptor positive (HR+) human epidermal growth factor receptor 2 negative (HER2-) metastatic breast cancer (HR+/HER2- mBC). Population Approach Group Europe ...
Wang X., et al. Disease Progression Modelling for Duchenne Muscular Dystrophy Using North Star Ambulatory Assessment and Forced Vital Capacity. 10th American Conference on Pharmacometrics. Orlando, FL; 2019. 除了疾病进展模型外,真实世界数据还可用于丰富和利用其他类型的模型为药物开发提供信息。
Table 1. Nucleotide sequences of primers and amplicon size used for real-time RT-qPCR amplification in human peripheral blood mononuclear cells (PBMCs). 2.5. Measurement of Produced Cytokines Interleukin 6 (IL6) and tumor necrosis factor alpha (TNFα) concentrations were analyzed in the superna...