We show that B-cell-enriched RGS13 is a direct transcriptional repressor of CREB. Phosphorylation of CREB induced RGS13 nuclear translocation, where it bound pCREB and inhibited CREB-DNA contact. RGS13 abundance affected pCREB promoter occupancy and CREB target gene transcription in HEK293T cells...
Regulator of G-protein signaling (RGS) is a protein superfamily discovered in the mid-1990s (Druey et al.1996; Watson et al.1996; Hunt et al.1996). Since that time more than 30 members in the family have been identified. The major physiological function of RGS molecules is to negatively...
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RGS13 Regulates Germinal Center B Lymphocytes Responsiveness to CXC Chemokine Ligand (CXCL)12 and CXCL13 Normal lymphoid tissue development and function depend upon directed cell migration. Providing guideposts for cell movement and positioning within lymphoid......
B Zheng,T Tang,N Tang,K Kudlicka,K Ohtsubo,P Ma,JD Marth,MG Farquhar,E Lehtonen 摘要: RGS-PX1 (also known as sorting nexin 13) is a member of both the regulator of G protein signaling (RGS) and sorting nexin (SNX) protein families. Biochemical and cell culture studies have shown ...
Cell... B Kreutz,N Hajicek,DM Yau,... - 《Cellular Signalling》 被引量: 47发表: 2007年 Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator. p115RhoGEF, a guanine nucleotide exchange factor (GEF) for Rho GTPase, is ...
Cell Biol. 8, 216–222 (1996). Article CAS Google Scholar Ross, E.M. & Wilkie, T.M. GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. Annu. Rev. Biochem. 69, 795–827 (2000). Article CAS Google Scholar Zheng,...
Sullivan, B.M. et al. RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport. Mol. Biol. Cell 11, 3155–3168 (2000). Article CAS Google Scholar Wells, C.D., Jiang, X., Gutowski, S. & Sternweis, P.C. Functional characterization of...
B, graph shows the luciferase reporter for Rho-dependent SRE activity of HEK 293T cells transfected with the indicated chimeras. Below, their ability to interact with RGL from PRG (AP RGL), their expression in total cell extracts (TCE), and their ability to promote the activation of ...
RGS13 Regulates Germinal Center B Lymphocytes Responsiveness to CXC Chemokine Ligand (CXCL)12 and CXCL13 Normal lymphoid tissue development and function depend upon directed cell migration. Providing guideposts for cell movement and positioning within lymphoid......