在RGMB-AS1过表达细胞中敲除NAA10后,GPX4水平增加,Fe2+水平降低,表明RGMB-AS1-NAA10也参与调节铁死亡(图5G和H)。综合来看,RGMB-AS1与NAA10的相互作用对于体外和体内肿瘤进展至关重要,RGMB-AS1-NAA10可能通过与HMG-CoA相关的铁死亡发挥作用。 6)RGMB-AS1通过依赖于HMOX1和NAA10的促进铁死亡机制抑制肿瘤进展 为了进...
Long non-coding RNA RGMB-AS1 (RGMB antisense RNA 1) plays a crucial role in tumor progression. However, its underlying mechanism in nasopharyngeal carcinoma (NPC) remains unclear. In this study, we analyzed the clinical significance of lncRNA RGMB-AS1 as a possible potential marker in NPC, ...
综合来看,RGMB-AS1与NAA10的相互作用对于体外和体内肿瘤进展至关重要,RGMB-AS1-NAA10可能通过与HMG-CoA相关的铁死亡发挥作用。 6)RGMB-AS1通过依赖于HMOX1和NAA10的促进铁死亡机制抑制肿瘤进展 为了进一步深入了解RGMB-AS1调控HMOX1和NAA10以增强肺癌铁死亡分子机制,我们分别通过敲除NAA10、shRNA敲低HMOX1以及将两者结...
Study on expression of lncRNA RGMB-AS1 and repulsive guidance molecule b in non-small cell lung cancer. Diagn Pathol 2015;10:63.Li P, Li J, Yang R, Zhang F, Wang H, Chu H, Lu Y, Dun S, Wang Y, Zang W, Du Y, Chen X, Zhao G, Zhang G. Study on expression of lncRNA ...
lncRNARGMB-AS1FOXA1细胞上皮间质转化目的:阐明LncRNARGMB-AS1通过调控FOXA1对鼻咽癌(NPC)细胞的增殖,迁移,上皮间充质转化及裸鼠成瘤的影响,并探讨其中涉及的潜在分子机制. 方法:1.首先采用RT-qPCR检测30例NPC确诊病例对应的NPC组织和NPC癌旁组织中lncRNARGMB-AS1与FOXA1的表达水平,并将lncRNARGMB-AS1与FOXA1在...
Conclusion Upregulation of LncRNA RGMB-AS1 can target upregulation of miR-574-3p to inhibit the proliferation, migration, and invasion of human prostate cancer cells, which may be attributed to downregulation of Cyclin D1, ZEB1, N-cadherin, VIM expressions, and ...
Repulsive guidance molecule b (RGMBlncRNA RGMB-AS1Non-small-cell lung cancers (NSCLCMedicine(GeneralPathologyThe relationships between lncRNAs and tumors have currently become one of the focuses on cancer studies. However, there are a few studies about lncRNAs in non-small cell lung cancer (NSCLC)...
Study on expression of lncRNA RGMB-AS1 and repulsive guidance molecule b in non-small cell lung cancer. Diagn Pathol 2015; 10: 63.Ping, Li,Juan,etc.Study on expression of lncRNA RGMB-AS1 and repulsive guidance molecule b in non-small cell lung cancer.[J].2015,10....