In vitro, RBM15 silencing enhanced the effects of radiation on the growth and invasion inhibition, and apoptosis induction of NSCLC cells; RBM15 overexpression had the opposite effects. Mechanistically, RBM15 induced CBR3-AS1 upregulation via an m6A-IGF2BP3-dependent mechanism, inducing CXCL1 ...
CBR3-AS1/miR-409-3p/CXCL1 axis.##RBM15 induces CBR3-AS1 via an m6A-IGF2BP3 mechanism, promoting NSCLC radioresistance.CBR3-AS1 induces CXCL1 by sponging miR-409-3p to recruit MDSCs and inhibit T cells.RBM15 is a radiosensitization target for NSCLC as the RBM15 depletion reverses the ...