RFamide neuropeptidesserotoninFMRFamide and the related tetrapeptide FLRFamide are highly excitatory in molluscan non-cardiac smooth muscle. They are also exceptionally excitatory in the atrium and internally perfused ventricle of Busycon canaliculatum. These two peptides, usually thought of as classic ...
The RFamide peptides or RFamide-related peptides (RFRPs) family are a large family of neuropeptides that are characterized by the possession of an Arg-Phe-NH2 motif at C-terminal extremities that is functionally critical [122]. From: Life Sciences, 2018 ...
both invertebrate and vertebrate. However, despite their fundamental importance to animal physiology and behaviour, they are much less well understood than the small molecule neurotransmitters. The neuropeptides are classified into families according to similarities...
Structure and functions of the novel hypothalamic RFamide neuropeptides R-RFa and 26RFa in vertebrates A number of RFamide peptides have been characterized in invertebrate species and these peptides have been found to exert a broad spectrum of biological act... N Chartrel,F Bruzzone,Jér?me Le...
Kivipelto L and Panula P.Central neuronal pathways containing FLFQPQRFamide-like (morphine-modulating) peptide and related neuropeptides in the rat brain.European Journal of Neuroscience. 1991Kivipelto, L. and Panula, P. (1991a) Central neuronal pathways containing FLFQPQRFamide-like (morphine-...
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In fruit flies and zebrafish, a single RFamide gene encodes neuropeptides that signal through one or possibly two receptors to regulate sleep. In contrast, the genetically tractable nematode, Caenorhabditis elegans, possesses >30 FMRFamide-related peptide genes (flp), multiple of which have been ...
E. (2005). LFRFamides: a novel family of parasitation-induced-RFamide neuropeptides that inhibit the activity of neuroendocrine cells in Lymnaea stagnalis . J. Neurochem. 92 , 1073–108010.1111/j.1471-4159.2004.02927.x [ Cross Ref ]
These RFamide neuropeptides were strongly inotropic on both ventricles and the atrium, while on the latter they were strongly chronotropic despite several of these peptides being of a non-molluscan origin. Chain length seems to be of little importance for activity at the receptor. Surprisingly, ...
The vertebrate reproductive cycle is controlled by several neuropeptides/hormones coordinating the activity of the hypothalamo-pituitary-gonadal axis. Gonadotropin-releasing hormone (GnRH) is a key hypothalamic decapeptide hormone known to modulate the biosynthesis and release of both gonadotropins, luteinizin...