In this study, we determined the cryo-EM structure of the G-coupled QRFPR bound to 26RFa. The structure reveals a unique assembly mode of the extracellular region of the receptor and the N-terminus of the peptid
Peptides致力研究多肽,多肽底物,自1983年以来Peptides生产和销售多种高纯度生物活性肽,西宝生物科技(上海)股份有限公司(简称 西宝生物 Seebio)成立于2003年2813月,从诊断领域起步,发展迅速,是中国生命科学领域集商贸进出口、研发、生产一体化的综合服务商,专业代理Peptides 公司简介 上海惠诚生物科技有限公司,成立于...
Pyroglutamylated RFamide Peptide (Human) 品牌:Peptide CAS No.: 储存条件:-20°C 纯度:– 产品编号 (生产商编号) 等级 规格 运输包装 零售价(RMB) 库存情况 参考值 334-44191 – 0.1mg – 咨询 – – * 干冰运输、大包装及大批量的产品需酌情添加运输费用 * 零售价、促销产品折扣、运输费用、...
Subchapter 1D. Pyroglutamylated RFamide PeptideQRFP was first identified in the brain of the European green frog. Subsequently, the cDNAs encoding the QRFP precursors were characterized in various animals, including goldfish, quail, chicken, zebra finch, mouse, rat, bovines, and human. QRFP was ...
Orphan receptor GPR103, a pyroglutamylated RFamide peptide receptor (QRFPR), is a class-A G protein-coupled receptor (GPCR) and it is coupled to a Gi alpha subunit (Gi/0) and/or to a Gq protein. Synteny analysis revealed the existence ofqrfprparalogous genes in mouse, zebrafish and ...
Positive selection effects on the biochemical properties of mammal pyroglutamylated RFamide peptide receptor (QRFPR)Phylogenymolecular evolutionpositive selectionorphan receptorOrphanreceptorGPR103,apyroglutamylatedRFamidepeptidereceptor(QRFPR),isaclassAGprotein-coupledreceptor(GPCR)anditiscoupledtoaGialphasubunit(...
Pyroglutamylated RFamide peptide receptor (QRFPR; GPR103)Mouse and in vitro studies suggest a GPR103 agonist could increase food intake to help treat anorexia.Science-Business eXchangedoi:10.1038/scibx.2012.815None
Energy metabolismQRFP is a neuropeptide that regulates glucose homeostasis and increases insulin sensitivity in tissues. We have previously shown that QRFP and its receptor (GPR103) are predominantly expressed in germ cells and Sertoli cells, respectively, in mice testes. In the present study, we ...
Subchapter 3D - Pyroglutamylated RFamide peptidePyroglutamylated RFamide peptide (QRFP)26RFaQRFPRGPR103Orexigenic peptideHypothalamusEnergy homeostasisBone formationPituitary hormone secretiondoi:10.1016/B978-0-12-820649-2.00007-3Kazuyoshi UkenaKazuyoshi Tsutsui...