For many, the genetic code was to provide the key to understanding protein synthesis. For those with a bit more sophistication, it was the Shine-Dalgarno region (in prokaryotes) or scanning and the Kozak consensus sequence (in eukaryotes). In all of these, the answer was in the nucleic ...
An example is Ser-racemase which catalyzes the synthesis of d-Ser-from l-Ser, the function of which is to act as a co-agonist with Glu-of the N-methyl-d-aspartate (NMDA) receptor, important in controlling synaptic plasticity and memory function (De Miranda et al., 2000; Smith et al....
Furthermore, disordered protein translation and signaling in the placenta can also cause ER stress in the syncytiotrophoblast, and has been demonstrated in placentas of IUGR patients [187]. ER stress inhibits placental protein synthesis, eventually triggering apoptosis [234]. Moreover, induction of...
tissues, which can hydrolyze protein drugs and make them lose their activity. At the same time, due to the filtration effect of glomeruli, molecules with molecular weights of less than 69 kDa are easily removed in the process of metabolism. Therefore, there has been some doubt whether the pro...
Besides, the inhibitors are designed against the most conserved region of the virus spike protein; they retain high potency to the existing pandemic variants and are most likely to be resilient to future changes. The de novo proteins can be precisely crafted as novel drugs, catalysts, and ...
35% of hNFL protein was still remaining [156]. These results show that a pre-existing NF network is a key determinant of half-lives of NF proteins by reducing their turnover rate and support the view that NF proteins can spend several months, if not years, in long NF-rich peripheral ...
(i.e., brain-derived neurotrophic factor and its receptor tropomyosin receptor kinase B), and increased autophagy through the blocking of protein phosphatase 2A activation [195,196]. However, these results failed to be replicated in transgenic models of α-Synuclein pathology [197]. Increased ...
“Review methodology” section details the processes underwent to arrive at the final studies assessed in this systematic literature review. Also, the data abstracted from the individual studies, their risk of bias rating, and the methods for result synthesis are detailed in this section. “Results...
Efficacy was measured by average protein prediction error, where CNN performed best (average error of 1.96 g protein). In order to estimate volume for calorie calculation when using imaging for dietary intake, the users’ thumb or distance estimation can be used [64]. Lo et al. [60] ...
The type of protein is important which should be high quality, evenly distributed through a day aiming to achieve an intake every 3 to 4 hours (53). Implications for future research Further longitudinal studies need to be undertaken to provide definitive evidence for a relationship between ...