Immunocytochemistry and cell‐surface biotinylation experiments revealed that γ‐secretase is recycled via the endosome‐to‐ trans ‐Golgi network transport. In addition, γ‐secretase is retrogradely transported by syntaxin 5/6, known as targets of Retro‐2, independent pathway. Conversely, TPT‐260...
Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated Background Retrograde transport of several transmembrane proteins from endosomes to the trans-Golgi network (TGN) occurs via Rab 5-containing endosomes, me....
Retrograde transport is where proteins and lipids are transported back from the plasma membrane (PM) and endosomes to the Golgi, and crucial for a diverse range of cellular functions. Recycling endosomes (REs) serve as a sorting station for the retrograd
Trasporto di proteine e membrane dalla superficie delle cellule di Golgi e oltre è essenziale per l'omeostasi, organello identità e fisiologia. Per studiare il traffico della proteina retrograda, abbiamo recentemente sviluppato un versatile basato su nanobody toolkit per analizzare il trasporto...
Long-distance axonal trafficking plays a critical role in neuronal function and transport defects have been linked to neurodegenerative disorders. Various lines of evidence suggest that the small GTPase Rab5 plays a role in neuronal signaling via early e
Post-Golgi anterograde transport requires GARP-dependent endosome-to-TGN retrograde transport The importance of endosome-to-trans-Golgi network (TGN) retrograde transport in the anterograde transport of proteins is unclear. In this study, genome-wide screening of the factors necessary for efficient anter...
Franch-Marro, X. et al. Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex.Nat. Cell Biol.10, 170–177 (2008). ArticleCASPubMedPubMed CentralGoogle Scholar Zhang, D. et al. RAB-6.2 and the retromer regulate glutamate receptor recycling thr...
VIP-21, AN INTEGRAL COMPONENT OF TRANS-GOLGI-NETWORK-DERIVED TRANSPORT VESICLES During the assembly of vaccinia virus, the intracellular mature virus becomes enwrapped by a cellular cisterna to form the intracellular enveloped virus (I... P Dupree,R Parton,T Kurzchalia,... - 《Molecular Biology...
Recent studies have shed new light on the structure and function of a heterotetrameric tethering factor named Golgi-associated retrograde protein (GARP), which promotes fusion of endosome-derived, retrograde transport carriers to the trans-Golgi network (TGN). X-ray crystallography of the Vps53 ...
Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin The retrograde transport pathways from early/recycling endosomes are critical for recycling a range of endogenous cargo, as well as internalisation of bact... ZL Zi,PA Gleeson - ...